Epidemiology and treatment approaches in management of invasive fungal infections in hematological malignancies: Results from a single-centre study

Invasive fungal infections (IFIs) are a leading cause of morbidity and attributable mortality in oncohematologic patients. Timely diagnosis is essential but challenging. Herein we retrospectively describe 221 cases of antifungal treatments (AFT) administered in a monocentric real-life cohort of hema...

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Veröffentlicht in:	PloS one 2019-05, Vol.14 (5), p.e0216715-e0216715
Hauptverfasser:	Fracchiolla, Nicola Stefano, Sciumè, Mariarita, Orofino, Nicola, Guidotti, Francesca, Grancini, Anna, Cavalca, Fabrizio, Freyrie, Alessandra, Goldaniga, Maria Cecilia, Consonni, Dario, Mattiello, Veronica, Pettine, Loredana, Cortelezzi, Agostino
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myelocytic leukemia Acute myeloid leukemia Adolescent Adult Aged Aged, 80 and over Antifungal agents Antifungal Agents - therapeutic use Antigens Biology and Life Sciences Blood diseases Cancer Cancer therapies Candidiasis, Invasive - complications Candidiasis, Invasive - drug therapy Candidiasis, Invasive - epidemiology Care and treatment Caspofungin CAT scans Chemotherapy Chi-square test Computed tomography Diagnosis Diagnostic imaging Diagnostic systems Epidemiology Female Fever Fluconazole Fungal infections Fungi Fungicides Hematologic Neoplasms - complications Hematology Humans Infection Infections Infectious diseases Invasive Fungal Infections - complications Invasive Fungal Infections - drug therapy Invasive Fungal Infections - epidemiology Invasive Pulmonary Aspergillosis - complications Invasive Pulmonary Aspergillosis - drug therapy Invasive Pulmonary Aspergillosis - epidemiology Invasiveness Itraconazole Leukemia Leukemia, Myeloid, Acute - complications Male Medical diagnosis Medical imaging Medicine and Health Sciences Middle Aged Morbidity Mortality Mycoses Myeloid leukemia Neutropenia Patient outcomes Physical Sciences Posaconazole Prophylaxis Research and Analysis Methods Retrospective Studies Stem cells Systematic review Tomography Treatment Outcome Young Adult
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Zusammenfassung:	Invasive fungal infections (IFIs) are a leading cause of morbidity and attributable mortality in oncohematologic patients. Timely diagnosis is essential but challenging. Herein we retrospectively describe 221 cases of antifungal treatments (AFT) administered in a monocentric real-life cohort of hematological malignancies. Between January 2010 and July 2017, 196 oncohematologic patients were treated with AFT at our Hematology Department. Diagnosis of IFIs was carried out according to EORTC/MSG-2008 guidelines.The most represented disease was acute myeloid leukemia (104 patients). Median age was 61 years; at fever onset 177 (80%) patients had a neutrophil count
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0216715