Prognostic value of baseline metabolic tumor volume and total lesion glycolysis in patients with lymphoma: A meta-analysis

Whether baseline metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) measured by FDG-PET/CT affected prognosis of patients with lymphoma was controversial. We searched PubMed, EMBASE and Cochrane to identify studies assessing the effect of baseline TMTV and TLG on the survival of lymphom...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0210224-e0210224
Hauptverfasser:	Guo, Baoping, Tan, Xiaohong, Ke, Qing, Cen, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biology and Life Sciences Cancer therapies CAT scans Chemotherapy Clinical decision making Confidence intervals Cyclophosphamide - therapeutic use Decision making Doxorubicin - therapeutic use Female Fluorodeoxyglucose F18 - therapeutic use Gene expression Glycolysis Glycolysis - genetics Humans Lymphoma Lymphoma, Large B-Cell, Diffuse - diagnostic imaging Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - epidemiology Lymphoma, Large B-Cell, Diffuse - metabolism Lymphomas Male Medical imaging Medical prognosis Medicine and Health Sciences Meta-analysis Metabolism Patients Physical Sciences Positron emission tomography Prognosis Progression-Free Survival Proportional Hazards Models Quality Radiopharmaceuticals - therapeutic use Research and Analysis Methods Studies Survival Tomography Tumor Burden Tumors Vincristine - therapeutic use
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Zusammenfassung:	Whether baseline metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) measured by FDG-PET/CT affected prognosis of patients with lymphoma was controversial. We searched PubMed, EMBASE and Cochrane to identify studies assessing the effect of baseline TMTV and TLG on the survival of lymphoma patients. Pooled hazard ratios (HR) for overall survival (OS) and progression-free survival (PFS) were calculated, along with 95% confidence intervals (CI). Twenty-seven eligible studies including 2,729 patients were analysed. Patients with high baseline TMTV showed a worse prognosis with an HR of 3.05 (95% CI 2.55-3.64, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0210224