Lack of NWC protein (c11orf74 homolog) in murine spermatogenesis results in reduced sperm competitiveness and impaired ability to fertilize egg cells in vitro

NWC is an uncharacterised protein containing three strongly conserved domains not found in any other known protein. Previously, we reported that the NWC protein is detected in cells in the germinal layer in murine testes (strain: C57BL/6), and its knockout results in no obvious phenotype. We determi...

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Veröffentlicht in:	PloS one 2018-12, Vol.13 (12), p.e0208649-e0208649
Hauptverfasser:	Majkowski, Michal, Laszkiewicz, Agnieszka, Sniezewski, Lukasz, Grzmil, Pawel, Pawlicka, Bernadetta, Tomczyk, Igor, Michniewicz, Martyna, Kapusniak, Violetta, Janik, Sylwia, Chodaczek, Grzegorz, Cebrat, Malgorzata
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal reproduction Animals Biology and Life Sciences Biomedical research Competitiveness Eggs Evolution Female Fertilization - physiology Fertilization in vitro Gene expression Genes Genetic aspects Homology Immunology In vitro fertilization Infertility Laboratories Localization Male Males Mating Medicine and Health Sciences Mice, Inbred C57BL Mice, Knockout Microscopy Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - genetics Organ Size Phenotypes Physical Sciences Proteins Reproductive system Research and Analysis Methods Sperm Sperm competition Sperm Count Sperm Motility - physiology Spermatids Spermatocytes Spermatogenesis Spermatogenesis - physiology Spermatozoa - metabolism Spermatozoa - pathology Testes Testis - metabolism Testis - pathology Zoology
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