Diffusion spectrum imaging in white matter microstructure in subjects with type 2 diabetes

This study aimed to investigate the feasibility and clinical applicability of Diffusion Spectrum Imaging (DSI) for quantitative detection of white matter microstructural integrity. Twenty-seven patients with type 2 diabetes mellitus (T2DM; aged 60.6±7.6 years) and 21 healthy controls (HC; aged 56.1±7.8 years) underwent high-resolution T1-weighted imaging and DSI scanning. Cognitive function scores were obtained using such instruments as the Montreal Cognitive Assessment (MoCA). The fasting blood glucose, glycated hemoglobin, and total cholesterol (CHO) of T2DM were measured. The bilateral uncinate fasciculus and superior cingulum bundle were reconstructed by DSI tractography. Statistical analysis was performed using SPSS 21.0 software and P