The relationship between serum hepatitis B virus DNA level and liver histology in patients with chronic HBV infection

There is no consensus regarding the relationship between HBV DNA and liver fibrosis, and the relationship between HBV DNA and the degree of liver cirrhosis has not been reported in patients with chronic HBV infection. From January 2011 to December 2016, liver biopsies were performed on 396 patients...

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Veröffentlicht in:	PloS one 2018-11, Vol.13 (11), p.e0206060-e0206060
Hauptverfasser:	Liu, Changjiang, Wang, Li, Xie, Huizhong, Zhang, Liyuan, Wang, Bingshu, Luo, Chun, Wang, Suiqun, Tang, Mingliang, Fu, Zhongbiao, Ruan, Hailan, Liu, Zhengjin, Wei, Ling, Yi, Wenyi, Xie, Yunqian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Biology and Life Sciences Biopsy Chronic infection Cirrhosis Deoxyribonucleic acid DNA Fibrosis Gastroenterology Hepatitis Hepatitis B Hepatitis B e antigen Histology Hospitals Hypotheses Infections Infectious diseases Interferon Liver Liver cancer Liver cirrhosis Liver diseases Medicine and Health Sciences Pathology Patients Scleroderma Sclerosis Sensitivity Serum levels Ultrasonic imaging Viruses
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Beschreibung
Zusammenfassung:	There is no consensus regarding the relationship between HBV DNA and liver fibrosis, and the relationship between HBV DNA and the degree of liver cirrhosis has not been reported in patients with chronic HBV infection. From January 2011 to December 2016, liver biopsies were performed on 396 patients with chronic hepatitis B and cirrhosis. Assessments of liver fibrosis and cirrhosis were based on the Laennec staging system. Serum levels of HBV DNA were correlated with fibrosis and cirrhosis (KW = 73.946, P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0206060