miRWalk: An online resource for prediction of microRNA binding sites

miRWalk is an open-source platform providing an intuitive interface that generates predicted and validated miRNA-binding sites of known genes of human, mouse, rat, dog and cow. The core of miRWalk is the miRNA target site prediction with the random-forest-based approach software TarPmiR searching th...

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Veröffentlicht in:PloS one 2018-10, Vol.13 (10), p.e0206239-e0206239
Hauptverfasser: Sticht, Carsten, De La Torre, Carolina, Parveen, Alisha, Gretz, Norbert
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Sprache:eng
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Zusammenfassung:miRWalk is an open-source platform providing an intuitive interface that generates predicted and validated miRNA-binding sites of known genes of human, mouse, rat, dog and cow. The core of miRWalk is the miRNA target site prediction with the random-forest-based approach software TarPmiR searching the complete transcript sequence including the 5'-UTR, CDS and 3'-UTR. Moreover, it integrates results other databases with predicted and validated miRNA-target interactions. The focus is set on a modular design and extensibility as well as a fast update cycle. The database is available using Python, MySQL and HTML/Javascript Database URL: http://mirwalk.umm.uni-heidelberg.de.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0206239