Induction of obesity impairs reverse cholesterol transport in ob/ob mice

Induction of obesity impairs reverse cholesterol transport in ob/ob mice

Obesity is an independent risk factor for cardiovascular disease. Reverse cholesterol transport (RCT) is an important cardioprotective mechanism. This study aimed to investigate RCT changes in a murine model of obesity. Ob/ob and control mice were injected with [3H]-cholesterol-labelled macrophages...

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Veröffentlicht in:PloS one 2018-09, Vol.13 (9), p.e0202102-e0202102
Hauptverfasser: Duong, MyNgan, Uno, Kiyoko, Nankivell, Victoria, Bursill, Christina, Nicholls, Stephen J
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes
Adipose tissue
Animal models
Animal tissues
Atherosclerosis
Bile
Biology
Biology and Life Sciences
Body fat
Cardiovascular diseases
Cholesterol
Control methods
Cytokines
Drug dosages
Efflux
Health risks
Heart
Hepatocytes
High density lipoprotein
Laboratory animals
Lipids
Liver
Low density lipoprotein
Macrophages
Medical research
Medicine and Health Sciences
Metabolism
Mice
Obesity
Proteins
Research and Analysis Methods
Risk analysis
Risk factors
Transport
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Zusammenfassung:Obesity is an independent risk factor for cardiovascular disease. Reverse cholesterol transport (RCT) is an important cardioprotective mechanism. This study aimed to investigate RCT changes in a murine model of obesity. Ob/ob and control mice were injected with [3H]-cholesterol-labelled macrophages and cholesterol accumulation quantified after 48 h. Ex vivo, cholesterol efflux and uptake were determined in hepatic and adipose tissues. Ob/ob mice had more labelled cholesterol in their plasma (86%, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0202102