Age- and sex-dependent changes in sympathetic activity of the left ventricular apex assessed by 18F-DOPA PET imaging

Sexual dimorphism in cardiac sympathetic outflow has recently gained attention in the context of Takotsubo cardiomyopathy. Previous studies suggest that there are sex- and age-dependent differences in peripheral autonomic control, however, data on cardiac-specific sympathetic activation in aged wome...

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Veröffentlicht in:	PloS one 2018-08, Vol.13 (8), p.e0202302
Hauptverfasser:	Burger, Irene A, Lohmann, Christine, Messerli, Michael, Bengs, Susan, Becker, Anton, Maredziak, Monika, Treyer, Valerie, Haider, Ahmed, Schwyzer, Moritz, Benz, Dominik C, Kudura, Ken, Fiechter, Michael, Giannopoulos, Andreas A, Fuchs, Tobias A, Gräni, Christoph, Pazhenkottil, Aju P, Gaemperli, Oliver, Buechel, Ronny R, Kaufmann, Philipp A, Gebhard, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Aged Aged, 80 and over Aging Aging - metabolism Autonomic nervous system Biology and Life Sciences Blood pressure Cardiology Cardiomyopathy Cardiovascular disease Child Child, Preschool Coronary vessels Diabetes Dihydroxyphenylalanine Emission analysis Family medical history Female Females Fluorine Fluorine isotopes Fluorine Radioisotopes Gender differences Heart Heart attacks Heart failure Heart Ventricles - diagnostic imaging Heart Ventricles - metabolism Hospitals Humans Hypertension Infant Male Medical diagnosis Medical imaging Medicine and Health Sciences Men Middle Aged Mortality Nervous system Neuroendocrine tumors Nuclear medicine Physical Sciences Positron emission Positron emission tomography Post-menopause Quantitative analysis Radiopharmaceuticals Regional analysis Regression analysis Regression models Research and Analysis Methods Retrospective Studies Sex Sex Characteristics Sexual dimorphism Sympathetic Nervous System - diagnostic imaging Sympathetic Nervous System - metabolism Tomography Tumors Ventricle Ventricles (cerebral) Women Young Adult
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Zusammenfassung:	Sexual dimorphism in cardiac sympathetic outflow has recently gained attention in the context of Takotsubo cardiomyopathy. Previous studies suggest that there are sex- and age-dependent differences in peripheral autonomic control, however, data on cardiac-specific sympathetic activation in aged women and men are lacking. Regional quantitative analysis of cardiac fluorine-18 (18F)- Dihydroxyphenylalanine (DOPA) uptake was retrospectively performed in 133 patients (69 females, mean age 52.4±17.7 years) referred for assessment of neuroendocrine tumours (NET) by Positron-Emission-Tomography. Cardiac 18F-DOPA uptake was significantly higher in women as compared to men (1.33±0.21 vs. 1.18±0.24, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0202302