A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects
Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviation. Restricting FODMAP intake is believed to relieve colonic distension...
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| creator | Sloan, Tim J Jalanka, Jonna Major, Giles A D Krishnasamy, Shanthi Pritchard, Sue Abdelrazig, Salah Korpela, Katri Singh, Gulzar Mulvenna, Claire Hoad, Caroline L Marciani, Luca Barrett, David A Lomer, Miranda C E de Vos, Willem M Gowland, Penny A Spiller, Robin C |
| description | Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviation. Restricting FODMAP intake is believed to relieve colonic distension by reducing colonic fermentation but this has not been previously directly assessed. We performed a randomised controlled trial comparing the effect of a low FODMAP diet combined with either maltodextrin or oligofructose on colonic contents, metabolites and microbiota.
A parallel randomised controlled trial in healthy adults (n = 37). All subjects followed a low FODMAP diet for a week and supplemented their diet with either maltodextrin (MD) or oligofructose (OF) 7g twice daily. Fasted assessments performed pre- and post-diet included MRI to assess colonic volume, breath testing for hydrogen and methane, and stool collection for microbiota analysis.
The low FODMAP diet was associated with a reduction in Bifidobacterium and breath hydrogen, which was reversed by oligofructose supplementation. The difference in breath hydrogen between groups post-intervention was 27ppm (95% CI 7 to 50, P |
| doi_str_mv | 10.1371/journal.pone.0201410 |
| format | Article |
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A parallel randomised controlled trial in healthy adults (n = 37). All subjects followed a low FODMAP diet for a week and supplemented their diet with either maltodextrin (MD) or oligofructose (OF) 7g twice daily. Fasted assessments performed pre- and post-diet included MRI to assess colonic volume, breath testing for hydrogen and methane, and stool collection for microbiota analysis.
The low FODMAP diet was associated with a reduction in Bifidobacterium and breath hydrogen, which was reversed by oligofructose supplementation. The difference in breath hydrogen between groups post-intervention was 27ppm (95% CI 7 to 50, P<0.01). Colonic volume increased significantly from baseline in both groups (OF increased 110ml (19.6%), 95% CI 30ml to 190ml, P = 0.01; MD increased 90ml (15.5%), 95% CI 6ml to 175ml, P = 0.04) with no significant difference between them. Colonic volumes correlated with total breath hydrogen + methane. A divergence in Clostridiales abundance was observed with increased abundance of Ruminococcaceae in the maltodextrin group, while in the oligofructose group, Lachnospiraceae decreased. Subjects in either group with high methane production also tended to have high microbial diversity, high colonic volume and greater abundance of methanogens.
A low FODMAP diet reduces total bacterial count and gas production with little effect on colonic volume.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0201410</identifier><identifier>PMID: 30048547</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abundance ; Adults ; Astronomy ; Biology and Life Sciences ; Biomedical research ; Carbohydrates ; Control methods ; Diet ; Dietary supplements ; Distension ; Divergence ; Earth Sciences ; Ecology and Environmental Sciences ; Fermentation ; Fructooligosaccharides ; Gas production ; Health aspects ; Hydrogen ; Hydrogen ion concentration ; Ingestion ; Intestine ; Irritable bowel syndrome ; Magnetic resonance imaging ; Maltodextrin ; Mansfield, Peter ; Medicine ; Medicine and Health Sciences ; Metabolites ; Methane ; Methane production ; Methanogenic bacteria ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Nutrient deficiency ; Nutrition research ; Pharmacy ; Physical Sciences ; Physics ; Polyols ; Prebiotics ; Randomization ; Reduction ; Research and Analysis Methods ; Saccharides ; Supplementation</subject><ispartof>PloS one, 2018-07, Vol.13 (7), p.e0201410-e0201410</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Sloan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Sloan et al 2018 Sloan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-685ccad6464dcb7161428524cbc99a49cfff0bd8c4eacfe7a5daed698ab18bb93</citedby><cites>FETCH-LOGICAL-c692t-685ccad6464dcb7161428524cbc99a49cfff0bd8c4eacfe7a5daed698ab18bb93</cites><orcidid>0000-0003-3668-7775 ; 0000-0001-5483-1027 ; 0000-0002-3847-8136</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062106/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062106/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30048547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sloan, Tim J</creatorcontrib><creatorcontrib>Jalanka, Jonna</creatorcontrib><creatorcontrib>Major, Giles A D</creatorcontrib><creatorcontrib>Krishnasamy, Shanthi</creatorcontrib><creatorcontrib>Pritchard, Sue</creatorcontrib><creatorcontrib>Abdelrazig, Salah</creatorcontrib><creatorcontrib>Korpela, Katri</creatorcontrib><creatorcontrib>Singh, Gulzar</creatorcontrib><creatorcontrib>Mulvenna, Claire</creatorcontrib><creatorcontrib>Hoad, Caroline L</creatorcontrib><creatorcontrib>Marciani, Luca</creatorcontrib><creatorcontrib>Barrett, David A</creatorcontrib><creatorcontrib>Lomer, Miranda C E</creatorcontrib><creatorcontrib>de Vos, Willem M</creatorcontrib><creatorcontrib>Gowland, Penny A</creatorcontrib><creatorcontrib>Spiller, Robin C</creatorcontrib><title>A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviation. Restricting FODMAP intake is believed to relieve colonic distension by reducing colonic fermentation but this has not been previously directly assessed. We performed a randomised controlled trial comparing the effect of a low FODMAP diet combined with either maltodextrin or oligofructose on colonic contents, metabolites and microbiota.
A parallel randomised controlled trial in healthy adults (n = 37). All subjects followed a low FODMAP diet for a week and supplemented their diet with either maltodextrin (MD) or oligofructose (OF) 7g twice daily. Fasted assessments performed pre- and post-diet included MRI to assess colonic volume, breath testing for hydrogen and methane, and stool collection for microbiota analysis.
The low FODMAP diet was associated with a reduction in Bifidobacterium and breath hydrogen, which was reversed by oligofructose supplementation. The difference in breath hydrogen between groups post-intervention was 27ppm (95% CI 7 to 50, P<0.01). Colonic volume increased significantly from baseline in both groups (OF increased 110ml (19.6%), 95% CI 30ml to 190ml, P = 0.01; MD increased 90ml (15.5%), 95% CI 6ml to 175ml, P = 0.04) with no significant difference between them. Colonic volumes correlated with total breath hydrogen + methane. A divergence in Clostridiales abundance was observed with increased abundance of Ruminococcaceae in the maltodextrin group, while in the oligofructose group, Lachnospiraceae decreased. Subjects in either group with high methane production also tended to have high microbial diversity, high colonic volume and greater abundance of methanogens.
A low FODMAP diet reduces total bacterial count and gas production with little effect on colonic volume.</description><subject>Abundance</subject><subject>Adults</subject><subject>Astronomy</subject><subject>Biology and Life Sciences</subject><subject>Biomedical research</subject><subject>Carbohydrates</subject><subject>Control methods</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Distension</subject><subject>Divergence</subject><subject>Earth Sciences</subject><subject>Ecology and Environmental Sciences</subject><subject>Fermentation</subject><subject>Fructooligosaccharides</subject><subject>Gas production</subject><subject>Health aspects</subject><subject>Hydrogen</subject><subject>Hydrogen ion concentration</subject><subject>Ingestion</subject><subject>Intestine</subject><subject>Irritable bowel syndrome</subject><subject>Magnetic resonance imaging</subject><subject>Maltodextrin</subject><subject>Mansfield, Peter</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolites</subject><subject>Methane</subject><subject>Methane production</subject><subject>Methanogenic bacteria</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Microorganisms</subject><subject>Nutrient deficiency</subject><subject>Nutrition research</subject><subject>Pharmacy</subject><subject>Physical Sciences</subject><subject>Physics</subject><subject>Polyols</subject><subject>Prebiotics</subject><subject>Randomization</subject><subject>Reduction</subject><subject>Research and Analysis 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low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects</title><author>Sloan, Tim J ; Jalanka, Jonna ; Major, Giles A D ; Krishnasamy, Shanthi ; Pritchard, Sue ; Abdelrazig, Salah ; Korpela, Katri ; Singh, Gulzar ; Mulvenna, Claire ; Hoad, Caroline L ; Marciani, Luca ; Barrett, David A ; Lomer, Miranda C E ; de Vos, Willem M ; Gowland, Penny A ; Spiller, Robin C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-685ccad6464dcb7161428524cbc99a49cfff0bd8c4eacfe7a5daed698ab18bb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abundance</topic><topic>Adults</topic><topic>Astronomy</topic><topic>Biology and Life Sciences</topic><topic>Biomedical research</topic><topic>Carbohydrates</topic><topic>Control methods</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Distension</topic><topic>Divergence</topic><topic>Earth Sciences</topic><topic>Ecology and Environmental Sciences</topic><topic>Fermentation</topic><topic>Fructooligosaccharides</topic><topic>Gas production</topic><topic>Health aspects</topic><topic>Hydrogen</topic><topic>Hydrogen ion concentration</topic><topic>Ingestion</topic><topic>Intestine</topic><topic>Irritable bowel syndrome</topic><topic>Magnetic resonance imaging</topic><topic>Maltodextrin</topic><topic>Mansfield, Peter</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metabolites</topic><topic>Methane</topic><topic>Methane production</topic><topic>Methanogenic bacteria</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Microorganisms</topic><topic>Nutrient deficiency</topic><topic>Nutrition research</topic><topic>Pharmacy</topic><topic>Physical 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Caroline L</au><au>Marciani, Luca</au><au>Barrett, David A</au><au>Lomer, Miranda C E</au><au>de Vos, Willem M</au><au>Gowland, Penny A</au><au>Spiller, Robin C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-07-26</date><risdate>2018</risdate><volume>13</volume><issue>7</issue><spage>e0201410</spage><epage>e0201410</epage><pages>e0201410-e0201410</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviation. Restricting FODMAP intake is believed to relieve colonic distension by reducing colonic fermentation but this has not been previously directly assessed. We performed a randomised controlled trial comparing the effect of a low FODMAP diet combined with either maltodextrin or oligofructose on colonic contents, metabolites and microbiota.
A parallel randomised controlled trial in healthy adults (n = 37). All subjects followed a low FODMAP diet for a week and supplemented their diet with either maltodextrin (MD) or oligofructose (OF) 7g twice daily. Fasted assessments performed pre- and post-diet included MRI to assess colonic volume, breath testing for hydrogen and methane, and stool collection for microbiota analysis.
The low FODMAP diet was associated with a reduction in Bifidobacterium and breath hydrogen, which was reversed by oligofructose supplementation. The difference in breath hydrogen between groups post-intervention was 27ppm (95% CI 7 to 50, P<0.01). Colonic volume increased significantly from baseline in both groups (OF increased 110ml (19.6%), 95% CI 30ml to 190ml, P = 0.01; MD increased 90ml (15.5%), 95% CI 6ml to 175ml, P = 0.04) with no significant difference between them. Colonic volumes correlated with total breath hydrogen + methane. A divergence in Clostridiales abundance was observed with increased abundance of Ruminococcaceae in the maltodextrin group, while in the oligofructose group, Lachnospiraceae decreased. Subjects in either group with high methane production also tended to have high microbial diversity, high colonic volume and greater abundance of methanogens.
A low FODMAP diet reduces total bacterial count and gas production with little effect on colonic volume.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30048547</pmid><doi>10.1371/journal.pone.0201410</doi><tpages>e0201410</tpages><orcidid>https://orcid.org/0000-0003-3668-7775</orcidid><orcidid>https://orcid.org/0000-0001-5483-1027</orcidid><orcidid>https://orcid.org/0000-0002-3847-8136</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-07, Vol.13 (7), p.e0201410-e0201410 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2077343216 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Abundance Adults Astronomy Biology and Life Sciences Biomedical research Carbohydrates Control methods Diet Dietary supplements Distension Divergence Earth Sciences Ecology and Environmental Sciences Fermentation Fructooligosaccharides Gas production Health aspects Hydrogen Hydrogen ion concentration Ingestion Intestine Irritable bowel syndrome Magnetic resonance imaging Maltodextrin Mansfield, Peter Medicine Medicine and Health Sciences Metabolites Methane Methane production Methanogenic bacteria Microbiota Microbiota (Symbiotic organisms) Microorganisms Nutrient deficiency Nutrition research Pharmacy Physical Sciences Physics Polyols Prebiotics Randomization Reduction Research and Analysis Methods Saccharides Supplementation |
| title | A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T13%3A38%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20low%20FODMAP%20diet%20is%20associated%20with%20changes%20in%20the%20microbiota%20and%20reduction%20in%20breath%20hydrogen%20but%20not%20colonic%20volume%20in%20healthy%20subjects&rft.jtitle=PloS%20one&rft.au=Sloan,%20Tim%20J&rft.date=2018-07-26&rft.volume=13&rft.issue=7&rft.spage=e0201410&rft.epage=e0201410&rft.pages=e0201410-e0201410&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0201410&rft_dat=%3Cgale_plos_%3EA547820636%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2077343216&rft_id=info:pmid/30048547&rft_galeid=A547820636&rft_doaj_id=oai_doaj_org_article_baf301fd890543c188f98ec62f70859a&rfr_iscdi=true |