Dynamic re-immunization of off-treatment childhood cancer survivors: An implementation feasibility study

There are no universally approved re-vaccination guidelines for non-transplant pediatric cancer survivors. We hypothesized that by utilizing a response-based re-vaccination schedule, we could tailor vaccine schedules in off-treatment cancer survivors. Pre-vaccination antibody levels were obtained in...

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Veröffentlicht in:PloS one 2018-02, Vol.13 (2), p.e0191804-e0191804
Hauptverfasser: Han, Jennifer H, Harmoney, Kathryn M, Dokmeci, Elif, Torrez, Jacqueline, Chavez, Cathy M, Cordova de Ortega, Loretta, Kuttesch, John F, Muller, Martha, Winter, Stuart S
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Sprache:eng
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Zusammenfassung:There are no universally approved re-vaccination guidelines for non-transplant pediatric cancer survivors. We hypothesized that by utilizing a response-based re-vaccination schedule, we could tailor vaccine schedules in off-treatment cancer survivors. Pre-vaccination antibody levels were obtained in 7 patients at an average of 20 days after the end of treatment date. In those without protective antibody levels, we administered vaccines 3 months after completion of treatment. Revaccinating patients 3 months after the end of treatment date resulted in protective antibody levels for most vaccines. We showed, on a preliminary basis, that vaccinating non-transplanted pediatric cancer survivors can be dynamically implemented in children with recovering immune function.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0191804