Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study

Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study

Metformin constitutes first-line treatment of type 2 diabetes mellitus. It is presumed to have lactic acidosis as a dangerous, but rare, side effect. To estimate the incidence rate of lactic acidosis in patients with type 2 diabetes mellitus as well as to estimate the relative risk of lactic acidosi...

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Veröffentlicht in:PloS one 2018-05, Vol.13 (5), p.e0196122
Hauptverfasser: Aharaz, Abdellatif, Pottegård, Anton, Henriksen, Daniel Pilsgaard, Hallas, Jesper, Beck-Nielsen, Henning, Lassen, Annmarie Touborg
Format: Artikel
Sprache:eng
Schlagworte:
Acidosis
Acidosis, Lactic - chemically induced
Acidosis, Lactic - epidemiology
Aged
Aged, 80 and over
Analysis
Antidiabetics
Biology and life sciences
Case-Control Studies
Comorbidity
Complications and side effects
Denmark - epidemiology
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - drug therapy
Dosage and administration
Drug therapy
Drug-Related Side Effects and Adverse Reactions - etiology
Emergency medical care
Endocrinology
Female
Glucose
Health risk assessment
Hemoglobin
Hospitals
Humans
Hypoglycemic Agents - adverse effects
Incidence
Lactic acid
Lactic acidosis
Male
Medicine and Health Sciences
Metformin
Metformin - adverse effects
Patients
People and Places
Pharmacy
Physical Sciences
Population
Prevalence studies (Epidemiology)
Regression analysis
Renal function
Risk analysis
Risk Factors
Studies
Type 2 diabetes
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Zusammenfassung:Metformin constitutes first-line treatment of type 2 diabetes mellitus. It is presumed to have lactic acidosis as a dangerous, but rare, side effect. To estimate the incidence rate of lactic acidosis in patients with type 2 diabetes mellitus as well as to estimate the relative risk of lactic acidosis associated with metformin treatment. This is a population-based combined cohort and case-control study among patients with type 2 diabetes mellitus who were acutely admitted with lactic acidosis at Odense University Hospital, Denmark; in the period from 1st June 2009 to 1st October 2013. The patients included as cases were all acutely hospitalized with lactic acidosis (pH
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0196122