Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study

Trauma is the leading cause of death and disability in patients aged 1-46 y. Severely injured patients experience considerable blood loss and hemorrhagic shock requiring treatment with massive transfusion of red blood cells (RBCs). Preclinical and retrospective human studies in trauma patients have...

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Veröffentlicht in:	PLoS medicine 2018-03, Vol.15 (3), p.e1002522-e1002522
Hauptverfasser:	Wagener, Brant M, Hu, Parker J, Oh, Joo-Yeun, Evans, Cilina A, Richter, Jillian R, Honavar, Jaideep, Brandon, Angela P, Creighton, Judy, Stephens, Shannon W, Morgan, Charity, Dull, Randal O, Marques, Marisa B, Kerby, Jeffrey D, Pittet, Jean-Francois, Patel, Rakesh P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Anesthesiology Animal models Animals Bacteria Bacterial infections Biology and Life Sciences Blocking antibodies Blood Blood cells Blood collection and preservation Blood transfusion Care and treatment Clonal deletion Complications and side effects Cross infection Deletion Development and progression Edema Erythrocyte Transfusion - adverse effects Erythrocyte Transfusion - methods Erythrocytes Erythrocytes - metabolism Female Health aspects Heme Hemolysis Hemopexin Hemopexin - analysis Hemorrhage Hemorrhage - etiology Hemorrhage - therapy Hemorrhagic shock HMGB1 protein HMGB1 Protein - analysis Humans Infections Inhibition Lungs Macrophages Male Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Models, Animal Mortality Neutrophils Pathology Patients Permeability Phagocytosis Physiological aspects Pneumonia - blood Pneumonia - etiology Pneumonia - mortality Pseudomonas aeruginosa Pseudomonas Infections - blood Pseudomonas Infections - etiology Pseudomonas Infections - mortality Rats Research and Analysis Methods Respiratory tract infections Risk factors Rodents Shock, Hemorrhagic - complications Sickle cell disease Signal Transduction Strain Supervision Surgery Survival Analysis TLR4 protein Toll-Like Receptor 4 - analysis Toll-Like Receptor 4 - antagonists & inhibitors Toll-like receptors Transfusion Transfusion Reaction - diagnosis Transfusion Reaction - metabolism Transfusion Reaction - mortality Trauma Wounds and Injuries - complications
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