Widespread disruption of functional brain organization in early-onset Alzheimer's disease

Early-onset Alzheimer's disease (AD) patients present a different clinical profile than late-onset AD patients. This can be partially explained by cortical atrophy, although brain organization might provide more insight. The aim of this study was to examine functional connectivity in early-onse...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102995-e102995
Hauptverfasser:	Adriaanse, Sofie M, Binnewijzend, Maja A A, Ossenkoppele, Rik, Tijms, Betty M, van der Flier, Wiesje M, Koene, Teddy, Smits, Lieke L, Wink, Alle Meije, Scheltens, Philip, van Berckel, Bart N M, Barkhof, Frederik
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age of Onset Aging Alzheimer Disease - physiopathology Alzheimer Disease - psychology Alzheimer's disease Atrophy Biology and Life Sciences Brain Brain - physiopathology Brain architecture Brain mapping Case-Control Studies Cognitive ability Correlation analysis Cortex Dementia Family medical history Female Functional magnetic resonance imaging Functional morphology Humans Magnetic Resonance Imaging Male Masks Medical imaging Medicine and Health Sciences Memory Middle Aged Neural networks Neurology Neuropsychological Tests Neurosciences NMR Nuclear magnetic resonance Nuclear medicine Pathology Patients Permutations Sensorimotor integration Sensory integration Tomography Visual system
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Zusammenfassung:	Early-onset Alzheimer's disease (AD) patients present a different clinical profile than late-onset AD patients. This can be partially explained by cortical atrophy, although brain organization might provide more insight. The aim of this study was to examine functional connectivity in early-onset and late-onset AD patients. Resting-state fMRI scans of 20 early-onset (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0102995