Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C

The PNPLA3 I148M sequence variant favors hepatic lipid accumulation and confers susceptibility to hepatic fibrosis and hepatocellular carcinoma. The aim of this study was to estimate the effect size of homozygosity for the PNPLA3 I148M variant (148M/M) on the fibrosis progression rate (FPR) and the...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e106022-e106022
Hauptverfasser:	De Nicola, Stella, Dongiovanni, Paola, Aghemo, Alessio, Cheroni, Cristina, D'Ambrosio, Roberta, Pedrazzini, Michele, Marabita, Francesco, Donnici, Lorena, Maggioni, Marco, Fargion, Silvia, Colombo, Massimo, De Francesco, Raffaele, Valenti, Luca
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Age determination Age Factors Aged Alcohol Alcoholic beverages Biopsy Body weight Chronic infection Chronology Diabetes Diabetes mellitus Disease Progression Fatty Liver - complications Fatty Liver - genetics Fibrosis Gastroenterology Gene Frequency Genetic Predisposition to Disease - genetics Genotype Genotype & phenotype Genotypes Hepatitis Hepatitis C Hepatitis C, Chronic - complications Hepatitis C, Chronic - genetics Hepatocellular carcinoma Hepatology Homozygosity Humans Infections Internal medicine Lipase - genetics Lipid Metabolism Liver - metabolism Liver - pathology Liver cancer Liver cirrhosis Liver Cirrhosis - complications Liver Cirrhosis - genetics Liver diseases Male Medicine Medicine and health sciences Membrane Proteins - genetics Metabolism Middle Aged Multivariate Analysis Mutation, Missense Overweight Patients Prospective Studies Risk Assessment Risk Factors Severity of Illness Index Steatosis Virology Young Adult
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Zusammenfassung:	The PNPLA3 I148M sequence variant favors hepatic lipid accumulation and confers susceptibility to hepatic fibrosis and hepatocellular carcinoma. The aim of this study was to estimate the effect size of homozygosity for the PNPLA3 I148M variant (148M/M) on the fibrosis progression rate (FPR) and the interaction with age at infection in chronic hepatitis C (CHC). FPR was estimated in a prospective cohort of 247 CHC patients without alcohol intake and diabetes, with careful estimation of age at infection and determination of fibrosis stage by Ishak score. Older age at infection was the strongest determinant of FPR (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0106022