Expression and immune responses to MAGE antigens predict survival in epithelial ovarian cancer

The MAGE cancer-testis antigens (CTA) are attractive candidates for immunotherapy. The aim of this study was to determine the frequency of expression, humoral immunity and prognostic significance of MAGE CTA in human epithelial ovarian cancer (EOC). mRNA or protein expression frequencies were determ...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104099-e104099
Hauptverfasser:	Daudi, Sayeema, Eng, Kevin H, Mhawech-Fauceglia, Paulette, Morrison, Carl, Miliotto, Anthony, Beck, Amy, Matsuzaki, Junko, Tsuji, Takemasa, Groman, Adrienne, Gnjatic, Sacha, Spagnoli, Guillo, Lele, Shashikant, Odunsi, Kunle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amino acids Antibodies Antigens Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Biology and Life Sciences Cancer Disease Progression Enzyme-Linked Immunosorbent Assay Female Gene expression Humans Humoral immunity Immune response Immunity Immunity, Humoral Immunohistochemistry Immunology Immunotherapy Kaplan-Meier Estimate Medicine and Health Sciences Melanoma Middle Aged mRNA Neoplasm Proteins - immunology Neoplasm Proteins - metabolism Oncology Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - immunology Ovarian Neoplasms - metabolism Pathology Patient outcomes Patients Prognosis Reverse Transcriptase Polymerase Chain Reaction Review boards RNA Survival Tumors
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Zusammenfassung:	The MAGE cancer-testis antigens (CTA) are attractive candidates for immunotherapy. The aim of this study was to determine the frequency of expression, humoral immunity and prognostic significance of MAGE CTA in human epithelial ovarian cancer (EOC). mRNA or protein expression frequencies were determined for MAGE-A1, -A3, -A4, -A10 and -C1 (CT7) in tissue samples obtained from 400 patients with EOC. The presence of autologous antibodies against the MAGE antigens was determined from 285 serum samples. The relationships between MAGE expression, humoral immunity to MAGE antigens, and clinico-pathologic characteristics were studied. The individual frequencies of expression were as follows: A1: 15% (42/281), A3: 36% (131/390), A4: 47% (186/399), A10: 52% (204/395), C1: 16% (42/267). Strong concordant expression was noted with MAGE-A1:-A4, MAGE-A1:-C1 and MAGE-A4:-A10 (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0104099