Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus

We performed a genome-wide association study (GWAS) of 1550 North American celiac disease cases and 3084 controls. Twelve SNPs, distributed across four regions (3p21.31, 4q27, 6q15, 6q25), were significantly associated with disease (p-value

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Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101428-e101428
Hauptverfasser:	Garner, Chad, Ahn, Richard, Ding, Yuan Chun, Steele, Linda, Stoven, Samantha, Green, Peter H, Fasano, Alessio, Murray, Joseph A, Neuhausen, Susan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Americas - epidemiology Autoimmune diseases Autophagy Biology and Life Sciences Biopsy Celiac disease Celiac Disease - complications Celiac Disease - epidemiology Celiac Disease - genetics Chromosome 6 Chromosomes Colitis Colitis, Microscopic - complications Colitis, Microscopic - genetics Consortia Crohn's disease Crohns disease Dermatitis Dermatitis herpetiformis Dermatitis Herpetiformis - complications Dermatitis Herpetiformis - genetics Disease control Epidemiology Gastroenterology Genetic Loci - genetics Genome-wide association studies Genome-Wide Association Study Genomes Genotype & phenotype Hepatology Humans Immunology Inflammatory bowel disease Loci Medical records Medicine and Health Sciences Polymorphism, Single Nucleotide Population Small intestine Studies
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Beschreibung
Zusammenfassung:	We performed a genome-wide association study (GWAS) of 1550 North American celiac disease cases and 3084 controls. Twelve SNPs, distributed across four regions (3p21.31, 4q27, 6q15, 6q25), were significantly associated with disease (p-value
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0101428