The influence of age, anthropometric and metabolic variables on LDIFLARE and corneal confocal microscopy in healthy individuals

The laser Doppler imaging (LDI) FLARE and corneal confocal microscopy (CCM) are reliable markers of small fibre function (SFF) and structure (SFS), respectively, but the impact of potential confounding variables needs to be defined. The objective of this study was to determine the influence of age,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2018-03, Vol.13 (3), p.e0193452-e0193452
Hauptverfasser:	Sharma, Sanjeev, Tobin, Victoria, Vas, Prashanth R J, Malik, Rayaz A, Rayman, Gerry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Age factors Aged Aging - metabolism Aging - pathology Anthropometry Biology and Life Sciences Blood Pressure Body mass Body Mass Index Body measurements Cholesterol Cholesterol - metabolism Confocal microscopy Cornea Cornea - anatomy & histology Cornea - blood supply Cornea - metabolism Correlation Cross-Sectional Studies Diabetes Diabetic neuropathy Doppler effect Fasting Female Fibers Glucose Hemoglobin Humans Laser-Doppler Flowmetry Linear Models Longitudinal Studies Male Males Medicine and Health Sciences Metabolism Methods Microcirculation - physiology Microscopy Microscopy, Confocal Middle Aged Morphology Multivariate Analysis Parameters Peripheral neuropathy Research and Analysis Methods Structure-function relationships Studies Thyroid gland Triglycerides Triglycerides - metabolism Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The laser Doppler imaging (LDI) FLARE and corneal confocal microscopy (CCM) are reliable markers of small fibre function (SFF) and structure (SFS), respectively, but the impact of potential confounding variables needs to be defined. The objective of this study was to determine the influence of age, anthropometric and biochemical variables on LDI and CCM. 80 healthy volunteers (43 males) (age: 39.7±15.2 yrs.) underwent LDIFLARE and CCM assessment and the effect of age, anthropometric and biochemical variables was determined using multivariate analysis. There was an age-related decline in LDIFLARE (0.07cm2/yr; R2 = 0.669; p =
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0193452