Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma

Lactoferrin (LF), a member of the transferrin family, recently has been demonstrated to have anticancer effects on various cancers including oral squamous cell carcinoma (OSCC). However, little is known about the underlying mechanisms of its effects on OSCC. Therefore, we aimed to investigate the me...

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Veröffentlicht in:	PloS one 2018-01, Vol.13 (1), p.e0191683-e0191683
Hauptverfasser:	Chea, Chanbora, Miyauchi, Mutsumi, Inubushi, Toshihiro, Febriyanti Ayuningtyas, Nurina, Subarnbhesaj, Ajiravudh, Nguyen, Phuong Thao, Shrestha, Madhu, Haing, Sivmeng, Ohta, Kouji, Takata, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Analysis Animals Anticancer properties Antimitotic agents Antineoplastic agents Apoptosis Biology and Life Sciences Breast cancer Cancer therapies Carcinoma, Squamous Cell - pathology Care and treatment Cattle Cell cycle Cell Cycle - drug effects Cell growth Cell Line, Transformed Cell proliferation Cell Proliferation - drug effects Cytokines Cytometry Diagnosis Dosage and administration Epithelial cells Flow cytometry Health sciences Humans Keratinocytes Kinases Lactoferrin Lactoferrin - pharmacology Lactoferrins Leukemia Mouth Neoplasms - pathology NF-κB protein Oral cancer Oral squamous cell carcinoma p53 Protein Pathways Penicillin Phosphorylation Proteins Rapamycin S phase Signal transduction Signaling SOCS-3 protein Squamous cell carcinoma Stat3 protein Studies TOR protein Transferrin Transferrins Tumor suppressor genes Western blotting
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