High Prevalence and Onward Transmission of Non-Pandemic HIV-1 Subtype B Clades in Northern and Northeastern Brazilian Regions

High Prevalence and Onward Transmission of Non-Pandemic HIV-1 Subtype B Clades in Northern and Northeastern Brazilian Regions

The Human immunodeficiency virus type-1 (HIV-1) epidemic in Brazil is mainly driven by the subtype B pandemic lineage (BPANDEMIC), while Caribbean non-pandemic subtype B clades (BCAR) seem to account for a very low fraction of HIV-infections in this country. The molecular characteristics of the HIV-...

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Veröffentlicht in:PloS one 2016-09, Vol.11 (9), p.e0162112-e0162112
Hauptverfasser: Divino, Flavia, de Lima Guerra Corado, Andre, Gomes Naveca, Felipe, Stefani, Mariane M A, Bello, Gonzalo
Format: Artikel
Sprache:eng
Schlagworte:
Acquired immune deficiency syndrome
AIDS
Analysis
Bayes Theorem
Bayesian analysis
Biology and Life Sciences
Brazil - epidemiology
Caribbean Region
Disease transmission
Earth Sciences
Ecology and Environmental Sciences
Epidemics
Epidemiology
Health aspects
HIV
HIV Infections - epidemiology
HIV Infections - transmission
HIV Infections - virology
HIV-1 - physiology
Human immunodeficiency virus
Humans
Infection
Infections
Likelihood Functions
Medicine and Health Sciences
Outbreaks
Pandemics
People and places
Phylogenetics
Phylogeny
Prevalence
Protease inhibitors
Research and Analysis Methods
Spatio-Temporal Analysis
Strains (organisms)
Viruses
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Zusammenfassung:The Human immunodeficiency virus type-1 (HIV-1) epidemic in Brazil is mainly driven by the subtype B pandemic lineage (BPANDEMIC), while Caribbean non-pandemic subtype B clades (BCAR) seem to account for a very low fraction of HIV-infections in this country. The molecular characteristics of the HIV-1 subtype B strains disseminated in the Northern and Northeastern Brazilian regions, however, have not been explored so far. In this study, we estimate the prevalence of the HIV-1 BPANDEMIC and BCAR clades across different Brazilian regions and we reconstruct the spatiotemporal dynamics of dissemination of the major Brazilian BCAR clades. A total of 2,682 HIV-1 subtype B pol sequences collected from 21 different Brazilian states from the five country regions between 1998 and 2013 were analyzed. Maximum Likelihood phylogenetic analyses revealed that the BCAR strains reached 16 out 21 Brazilian states here analyzed. The BCAR clades comprise a low fraction (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0162112