Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology

Recently, a role of the receptor for advanced glycation endproducts (RAGE) in myasthenia gravis was described. RAGE and its ligand high mobility group box 1 (HMGB1) play key roles in autoimmunity and cancer. To test whether these molecules are involved in patients with thymic abnormalities we applie...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94118-e94118
Hauptverfasser:	Moser, Bernhard, Janik, Stefan, Schiefer, Ana-Iris, Müllauer, Leonhard, Bekos, Christine, Scharrer, Anke, Mildner, Michael, Rényi-Vámos, Ferenc, Klepetko, Walter, Ankersmit, Hendrik Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adolescent Adult Advanced glycosylation end products Analysis Biology and Life Sciences Cancer Carcinoma Chromosomal proteins Corpuscles Cortex Dendritic cells Deoxyribonucleic acid Diagnostic systems DNA Epithelial cells Epithelial tumors Female Fetus - metabolism Fetuses Gene Expression Genetic aspects Glycosylation Health aspects HMGB1 protein HMGB1 Protein - blood HMGB1 Protein - genetics HMGB1 Protein - metabolism Humans Hyperplasia Immunohistochemistry Infant Invasiveness Laboratories Ligands Macrophages Male Medicine and Health Sciences Medulla Medulla oblongata Metastasis Middle Aged Morphology Myasthenia Myasthenia gravis Myasthenia Gravis - metabolism Myasthenia Gravis - pathology Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Neuromuscular junctions Pathogenesis Pathology Patients Physiological aspects Receptor for Advanced Glycation End Products Receptors, Immunologic - blood Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Research and Analysis Methods Rodents Serum levels Signal transduction Staining Surgery Thoracic surgery Thymocytes Thymus Thymus Gland - metabolism Thymus Hyperplasia - metabolism Thymus Hyperplasia - pathology Thymus Neoplasms - metabolism Thymus Neoplasms - pathology Tumors Young Adult
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Zusammenfassung:	Recently, a role of the receptor for advanced glycation endproducts (RAGE) in myasthenia gravis was described. RAGE and its ligand high mobility group box 1 (HMGB1) play key roles in autoimmunity and cancer. To test whether these molecules are involved in patients with thymic abnormalities we applied immunohistochemical analysis in 33 cases of thymic epithelial tumors, comprising 27 thymomas and 6 thymic carcinomas, and 21 nonneoplastic thymuses. Both molecules were detected in neoplastic epithelial cells: RAGE staining was most intense in WHO type B2 thymomas and thymic carcinomas (pB3>thymic carcinoma (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0094118