Cardiac function and architecture are maintained in a model of cardiorestricted overexpression of the prorenin-renin receptor

The (pro)renin-renin receptor, (P)RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P)RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. We therefore generated a transgen...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e89929-e89929
Hauptverfasser:	Mahmud, Hasan, Candido, Wellington Mardoqueu, van Genne, Linda, Vreeswijk-Baudoin, Inge, Yu, Hongjuan, van de Sluis, Bart, van Deursen, Jan, van Gilst, Wiek H, Silljé, Herman H W, de Boer, Rudolf A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acidification Angiotensin Angiotensins Animals Biology Blood Pressure Blotting, Western Cardiology Cardiomegaly - genetics Cardiomegaly - metabolism Cloning Creatine Kinase - metabolism Diabetes Echocardiography Experiments Fibrosis Gene expression Gene Expression Regulation - genetics Genetic engineering Heart Heart - physiology Heart diseases Heart failure HeLa Cells Humans Hypertension Hypertrophy Hypoxia Hypoxia - metabolism Ischemia Isoproterenol Kidneys Kinases L-Lactate Dehydrogenase - metabolism Laboratory animals Major histocompatibility complex Male Medicine Mice Mice, Transgenic Myocardium - metabolism Protein folding Real-Time Polymerase Chain Reaction Receptors, Cell Surface - metabolism Renin Reperfusion Reperfusion Injury - metabolism RNA Rodents Smooth muscle Transgenic animals Transgenic mice
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Beschreibung
Zusammenfassung:	The (pro)renin-renin receptor, (P)RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P)RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. We therefore generated a transgenic mouse (Tg) with cardio-restricted (P)RR overexpression driven by the alpha-MHC promotor. The mRNA expression of (P)RR was ∼ 170-fold higher (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0089929