PamR, a new MarR-like regulator affecting prophages and metabolic genes expression in Bacillus subtilis

B. subtilis adapts to changing environments by reprogramming its genetic expression through a variety of transcriptional regulators from the global transition state regulators that allow a complete resetting of the cell genetic expression, to stress specific regulators controlling only a limited num...

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Veröffentlicht in:PloS one 2017-12, Vol.12 (12), p.e0189694-e0189694
Hauptverfasser: De San Eustaquio-Campillo, Alba, Cornilleau, Charlène, Guérin, Cyprien, Carballido-López, Rut, Chastanet, Arnaud
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Sprache:eng
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Zusammenfassung:B. subtilis adapts to changing environments by reprogramming its genetic expression through a variety of transcriptional regulators from the global transition state regulators that allow a complete resetting of the cell genetic expression, to stress specific regulators controlling only a limited number of key genes required for optimal adaptation. Among them, MarR-type transcriptional regulators are known to respond to a variety of stresses including antibiotics or oxidative stress, and to control catabolic or virulence gene expression. Here we report the characterization of the ydcFGH operon of B. subtilis, containing a putative MarR-type transcriptional regulator. Using a combination of molecular genetics and high-throughput approaches, we show that this regulator, renamed PamR, controls directly its own expression and influence the expression of large sets of prophage-related and metabolic genes. The extent of the regulon impacted by PamR suggests that this regulator reprograms the metabolic landscape of B. subtilis in response to a yet unknown signal.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0189694