Sevoflurane causes greater QTc interval prolongation in chronically hyperglycemic patients than in normoglycemic patients

QTc interval prolongation is a serious diabetic complication and increases mortality rate. Hyperglycemia inhibits the rapid component of delayed rectifier potassium channel currents (Ikr) and prolongs the QTc interval on electrocardiograms. Sevoflurane also inhibits the Ikr and causes QTc interval p...

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Veröffentlicht in:	PloS one 2017-12, Vol.12 (12), p.e0188555-e0188555
Hauptverfasser:	Kimura, Seishi, Nakao, Shinichi, Kitaura, Atsuhiro, Iwamoto, Tatushige, Houri, Kei, Matsushima, Mayuka, Hamasaki, Shinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anesthesia Anesthesiology Biology and life sciences Cardiac arrhythmia Complications and side effects Diabetes Diabetes mellitus Drugs Electrocardiography Glucose Health aspects Heart rate Hemoglobin Hyperglycemia Japan Long QT syndrome Medicine Medicine and health sciences Mortality Patients Physical Sciences Potassium Potassium channels Prolongation Properties Propofol Remifentanil Risk factors Sevoflurane Statistical analysis Studies University faculty
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