Sevoflurane causes greater QTc interval prolongation in chronically hyperglycemic patients than in normoglycemic patients

Sevoflurane causes greater QTc interval prolongation in chronically hyperglycemic patients than in normoglycemic patients

QTc interval prolongation is a serious diabetic complication and increases mortality rate. Hyperglycemia inhibits the rapid component of delayed rectifier potassium channel currents (Ikr) and prolongs the QTc interval on electrocardiograms. Sevoflurane also inhibits the Ikr and causes QTc interval p...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2017-12, Vol.12 (12), p.e0188555-e0188555
Hauptverfasser: Kimura, Seishi, Nakao, Shinichi, Kitaura, Atsuhiro, Iwamoto, Tatushige, Houri, Kei, Matsushima, Mayuka, Hamasaki, Shinichi
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Anesthesia
Anesthesiology
Biology and life sciences
Cardiac arrhythmia
Complications and side effects
Diabetes
Diabetes mellitus
Drugs
Electrocardiography
Glucose
Health aspects
Heart rate
Hemoglobin
Hyperglycemia
Japan
Long QT syndrome
Medicine
Medicine and health sciences
Mortality
Patients
Physical Sciences
Potassium
Potassium channels
Prolongation
Properties
Propofol
Remifentanil
Risk factors
Sevoflurane
Statistical analysis
Studies
University faculty
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:QTc interval prolongation is a serious diabetic complication and increases mortality rate. Hyperglycemia inhibits the rapid component of delayed rectifier potassium channel currents (Ikr) and prolongs the QTc interval on electrocardiograms. Sevoflurane also inhibits the Ikr and causes QTc interval prolongation. In fact, torsade de pointes occurred in a patient with poorly controlled diabetes mellitus during sevoflurane anesthesia. We enrolled 74 patients, including 37 normoglycemic patients (glycated hemoglobin [HbA1c]:
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0188555