Effectiveness of 32 versus 20 weeks of prednisolone in leprosy patients with recent nerve function impairment: A randomized controlled trial

While prednisolone is commonly used to treat recent nerve function impairment (NFI) in leprosy patients, the optimal treatment duration has not yet been established. In this "Treatment of Early Neuropathy in Leprosy" (TENLEP) trial, we evaluated whether a 32-week prednisolone course is mor...

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Veröffentlicht in:	PLoS neglected tropical diseases 2017-10, Vol.11 (10), p.e0005952-e0005952
Hauptverfasser:	Wagenaar, Inge, Post, Erik, Brandsma, Wim, Bowers, Bob, Alam, Khorshed, Shetty, Vanaja, Pai, Vivek, Husain, Sajid, Sigit Prakoeswa, Cita Rosita, Astari, Linda, Hagge, Deanna, Shah, Mahesh, Neupane, Kapil, Tamang, Krishna Bahadur, Nicholls, Peter, Richardus, Jan Hendrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Analysis Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Biology and Life Sciences Body weight Care and treatment Clinical trials Dosage and administration Double-Blind Method Drug Administration Schedule Drug therapy Duration Edema Female Hospitals Humans Impairment Laboratories Leprosy Leprosy - complications Leprosy - drug therapy Male Medicine Medicine and Health Sciences Middle Aged Nerves Nervous system diseases Neuropathy Patients Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - etiology Prednisolone Prednisolone - administration & dosage Prednisolone - therapeutic use Public health Randomization Research and Analysis Methods Skeletal muscle Supervision Testing Treatment outcome Tropical diseases Tumor necrosis factor-TNF Young Adult
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Zusammenfassung:	While prednisolone is commonly used to treat recent nerve function impairment (NFI) in leprosy patients, the optimal treatment duration has not yet been established. In this "Treatment of Early Neuropathy in Leprosy" (TENLEP) trial, we evaluated whether a 32-week prednisolone course is more effective than a 20-week course in restoring and improving nerve function. In this multi-centre, triple-blind, randomized controlled trial, leprosy patients who had recently developed clinical NFI (
ISSN:	1935-2735 1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0005952