Survival and predictors of death in people with HIV-associated lymphoma compared to those with a diagnosis of lymphoma in general population

to compare overall survival in HIV-associated lymphoma (HIV-L) and lymphoma raising in HIV-negative population (nHIV-L) and to identify predictors of increased risk of death. All HIV+ patients with HIV-associated lymphoma (Hodgkin lymphoma, HL; non-Hodgkin Lymphoma, NHL) observed between 1.2000 and...

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Veröffentlicht in:PloS one 2017-10, Vol.12 (10), p.e0186549-e0186549
Hauptverfasser: Cingolani, Antonella, Cozzi Lepri, Alessandro, Teofili, Luciana, Galli, Laura, Mazzotta, Valentina, Baldin, Gian Maria, Hohaus, Stefan, Bandera, Alessandra, Alba, Lucia, Galizzi, Nadia, Castagna, Antonella, D'arminio Monforte, Antonella, Antinori, Andrea
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Sprache:eng
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Zusammenfassung:to compare overall survival in HIV-associated lymphoma (HIV-L) and lymphoma raising in HIV-negative population (nHIV-L) and to identify predictors of increased risk of death. All HIV+ patients with HIV-associated lymphoma (Hodgkin lymphoma, HL; non-Hodgkin Lymphoma, NHL) observed between 1.2000 and 12.2013 in the ICONA Foundation Study cohort or in three collaborating centres, and, as control group, nHIV-L individuals followed in one of the four collaborating centres over the same time period, were included. Survival estimates were calculated by use of Kaplan-Meier (KM) and multivariable Cox regression models. 1,331 pts were included (465 HIV-L, 866 nHIV-L): 909 (68%) NHL, 422 (32%) HL. 3 years-cumulative probability (95% confidence interval, CI) of death was higher in HIV-L compared to nHIV-L in NHL (38% (33-44) vs. 22% (19-26); p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0186549