RNA-Seq Reveals the Angiogenesis Diversity between the Fetal and Adults Bone Mesenchyme Stem Cell
In this research, we used RNA sequencing (RNA-seq) to analyze 23 single cell samples and 2 bulk cells sample from human adult bone mesenchyme stem cell line and human fetal bone mesenchyme stem cell line. The results from the research demonstrated that there were big differences between two cell lin...
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| Veröffentlicht in: | PloS one 2016-02, Vol.11 (2), p.e0149171-e0149171 |
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| creator | Zhao, Xin Han, Yingmin Liang, Yu Nie, Chao Wang, Jian |
| description | In this research, we used RNA sequencing (RNA-seq) to analyze 23 single cell samples and 2 bulk cells sample from human adult bone mesenchyme stem cell line and human fetal bone mesenchyme stem cell line. The results from the research demonstrated that there were big differences between two cell lines. Adult bone mesenchyme stem cell lines showed a strong trend on the blood vessel differentiation and cell motion, 48/49 vascular related differential expressed genes showed higher expression in adult bone mesenchyme stem cell lines (Abmsc) than fetal bone mesenchyme stem cell lines (Fbmsc). 96/106 cell motion related genes showed the same tendency. Further analysis showed that genes like ANGPT1, VEGFA, FGF2, PDGFB and PDGFRA showed higher expression in Abmsc. This work showed cell heterogeneity between human adult bone mesenchyme stem cell line and human fetal bone mesenchyme stem cell line. Also the work may give an indication that Abmsc had a better potency than Fbmsc in the future vascular related application. |
| doi_str_mv | 10.1371/journal.pone.0149171 |
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The results from the research demonstrated that there were big differences between two cell lines. Adult bone mesenchyme stem cell lines showed a strong trend on the blood vessel differentiation and cell motion, 48/49 vascular related differential expressed genes showed higher expression in adult bone mesenchyme stem cell lines (Abmsc) than fetal bone mesenchyme stem cell lines (Fbmsc). 96/106 cell motion related genes showed the same tendency. Further analysis showed that genes like ANGPT1, VEGFA, FGF2, PDGFB and PDGFRA showed higher expression in Abmsc. This work showed cell heterogeneity between human adult bone mesenchyme stem cell line and human fetal bone mesenchyme stem cell line. Also the work may give an indication that Abmsc had a better potency than Fbmsc in the future vascular related application.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0149171</identifier><identifier>PMID: 26901069</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Adult Stem Cells - cytology ; Adult Stem Cells - metabolism ; Adults ; Angiogenesis ; Bioinformatics ; Biology and Life Sciences ; Biotechnology ; Cell lines ; Cells, Cultured ; Deoxyribonucleic acid ; DNA ; Female ; Fetus - cytology ; Fetus - metabolism ; Fetuses ; Fibroblast growth factor 2 ; Gene expression ; Gene Expression Regulation ; Gene sequencing ; Genes ; Genomes ; Genomics ; Humans ; Hypoxia ; Liver cancer ; Male ; Medicine and Health Sciences ; Mesenchymal stem cells ; Mesenchymal Stem Cells - cytology ; Mesenchymal Stem Cells - metabolism ; Mesenchyme ; Middle Aged ; Neovascularization, Physiologic ; People and Places ; Research and Analysis Methods ; Ribonucleic acid ; RNA ; Stem cells ; Vascular endothelial growth factor</subject><ispartof>PloS one, 2016-02, Vol.11 (2), p.e0149171-e0149171</ispartof><rights>2016 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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The results from the research demonstrated that there were big differences between two cell lines. Adult bone mesenchyme stem cell lines showed a strong trend on the blood vessel differentiation and cell motion, 48/49 vascular related differential expressed genes showed higher expression in adult bone mesenchyme stem cell lines (Abmsc) than fetal bone mesenchyme stem cell lines (Fbmsc). 96/106 cell motion related genes showed the same tendency. Further analysis showed that genes like ANGPT1, VEGFA, FGF2, PDGFB and PDGFRA showed higher expression in Abmsc. This work showed cell heterogeneity between human adult bone mesenchyme stem cell line and human fetal bone mesenchyme stem cell line. Also the work may give an indication that Abmsc had a better potency than Fbmsc in the future vascular related application.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult Stem Cells - cytology</subject><subject>Adult Stem Cells - metabolism</subject><subject>Adults</subject><subject>Angiogenesis</subject><subject>Bioinformatics</subject><subject>Biology and Life Sciences</subject><subject>Biotechnology</subject><subject>Cell lines</subject><subject>Cells, Cultured</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Female</subject><subject>Fetus - cytology</subject><subject>Fetus - metabolism</subject><subject>Fetuses</subject><subject>Fibroblast growth factor 2</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Gene sequencing</subject><subject>Genes</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Liver cancer</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Mesenchymal Stem Cells - metabolism</subject><subject>Mesenchyme</subject><subject>Middle Aged</subject><subject>Neovascularization, Physiologic</subject><subject>People and Places</subject><subject>Research and Analysis Methods</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Stem cells</subject><subject>Vascular endothelial growth factor</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1vEzEUXCEQLYV_gMASFy4b_LX-uCCFQKFSAamFs-X1vk022l2nthOUf4_TbKsWcbJlz8ybN5qieE3wjDBJPqz9Noy2n238CDNMuCaSPClOiWa0FBSzpw_uJ8WLGNcYV0wJ8bw4oUJjgoU-LezVj3l5DTfoCnZg-4jSCtB8XHZ-CSPELqLP3Q5C7NIe1ZD-AIy3kHNItkd2bNC82fYpok_ZBvoOEUa32g-ArhMMaAF9_7J41mZheDWdZ8Xv8y-_Ft_Ky59fLxbzy9JVVKSy5Rhq1dBKEIotECGdFq7GVOKaE6KoAlw3TDuFReUoVq2kjkhRS5CV1IqdFW-PupveRzOlEw3RFa5yDkxmxMUR0Xi7NpvQDTbsjbeduX3wYWlsSJ3rwVRK6pY3oFotuT1MYa6mhAuoqZK2zVofp2nbeoDGwZiC7R-JPv4Zu5VZ-p3hUnCqRRZ4PwkEf7OFmMzQRZfzsiP4bfYthdREcKYz9N0_0P9vx48oF3yMAdp7MwSbQ2PuWObQGDM1JtPePFzknnRXEfYXE0W9qg</recordid><startdate>20160222</startdate><enddate>20160222</enddate><creator>Zhao, Xin</creator><creator>Han, Yingmin</creator><creator>Liang, Yu</creator><creator>Nie, Chao</creator><creator>Wang, Jian</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160222</creationdate><title>RNA-Seq Reveals the Angiogenesis Diversity between the Fetal and Adults Bone Mesenchyme Stem Cell</title><author>Zhao, Xin ; Han, Yingmin ; Liang, Yu ; Nie, Chao ; Wang, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-f40eb8d256120ae167c96cb0270b411828e0bd39c8065c208f72c176b7e757983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult Stem Cells - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Xin</au><au>Han, Yingmin</au><au>Liang, Yu</au><au>Nie, Chao</au><au>Wang, Jian</au><au>Kerkis, Irina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RNA-Seq Reveals the Angiogenesis Diversity between the Fetal and Adults Bone Mesenchyme Stem Cell</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-02-22</date><risdate>2016</risdate><volume>11</volume><issue>2</issue><spage>e0149171</spage><epage>e0149171</epage><pages>e0149171-e0149171</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In this research, we used RNA sequencing (RNA-seq) to analyze 23 single cell samples and 2 bulk cells sample from human adult bone mesenchyme stem cell line and human fetal bone mesenchyme stem cell line. The results from the research demonstrated that there were big differences between two cell lines. Adult bone mesenchyme stem cell lines showed a strong trend on the blood vessel differentiation and cell motion, 48/49 vascular related differential expressed genes showed higher expression in adult bone mesenchyme stem cell lines (Abmsc) than fetal bone mesenchyme stem cell lines (Fbmsc). 96/106 cell motion related genes showed the same tendency. Further analysis showed that genes like ANGPT1, VEGFA, FGF2, PDGFB and PDGFRA showed higher expression in Abmsc. This work showed cell heterogeneity between human adult bone mesenchyme stem cell line and human fetal bone mesenchyme stem cell line. Also the work may give an indication that Abmsc had a better potency than Fbmsc in the future vascular related application.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26901069</pmid><doi>10.1371/journal.pone.0149171</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Adult Stem Cells - cytology Adult Stem Cells - metabolism Adults Angiogenesis Bioinformatics Biology and Life Sciences Biotechnology Cell lines Cells, Cultured Deoxyribonucleic acid DNA Female Fetus - cytology Fetus - metabolism Fetuses Fibroblast growth factor 2 Gene expression Gene Expression Regulation Gene sequencing Genes Genomes Genomics Humans Hypoxia Liver cancer Male Medicine and Health Sciences Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Middle Aged Neovascularization, Physiologic People and Places Research and Analysis Methods Ribonucleic acid RNA Stem cells Vascular endothelial growth factor |
| title | RNA-Seq Reveals the Angiogenesis Diversity between the Fetal and Adults Bone Mesenchyme Stem Cell |
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