Alleles of HLA-DRB104 Associated with Pulmonary Tuberculosis in Amazon Brazilian Population

Alleles of HLA-DRB104 Associated with Pulmonary Tuberculosis in Amazon Brazilian Population

Immunogenetic host factors are associated with susceptibility or protection to tuberculosis (TB). Strong associations of HLA class II genes with TB are reported. We analyzed the HLA-DRB1*04 alleles to identify subtypes associated with pulmonary TB and their interaction with risk factors such as alco...

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Veröffentlicht in:PloS one 2016-02, Vol.11 (2), p.e0147543-e0147543
Hauptverfasser: Souza de Lima, Dhêmerson, Morishi Ogusku, Mauricio, Porto Dos Santos, Maisa, de Melo Silva, Cláudia Maria, Alves de Almeida, Vanessa, Assumpção Antunes, Irineide, Boechat, Antonio Luiz, Ramasawmy, Rajendranath, Sadahiro, Aya
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Alcohol
Alcohol use
Alcohols
Alleles
Antigens
Biology and Life Sciences
Brazil
Deoxyribonucleic acid
Diabetes
Disease
Disease transmission
DNA
Drb1 protein
Female
Genetic Predisposition to Disease - genetics
Histocompatibility antigen HLA
HLA-DRB1 Chains - genetics
Humans
Immunogenetics
Immunology
Male
Medicine and Health Sciences
Middle Aged
Patients
People and places
Polymorphism, Genetic - genetics
Population
Research and Analysis Methods
Rheumatoid arthritis
Risk analysis
Risk factors
Smoking
Social Sciences
Studies
Tuberculosis
Tuberculosis, Pulmonary - genetics
Young Adult
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Zusammenfassung:Immunogenetic host factors are associated with susceptibility or protection to tuberculosis (TB). Strong associations of HLA class II genes with TB are reported. We analyzed the HLA-DRB1*04 alleles to identify subtypes associated with pulmonary TB and their interaction with risk factors such as alcohol, smoking, and gender in 316 pulmonary TB patients and 306 healthy individuals from the Brazilian Amazon. The HLA-DRB1*04 was prevalent in patients with pulmonary TB (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0147543