Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer

The tumour immune microenvironment is considered to influence cancer behaviour and outcome. Using a panel of markers for innate and adaptive immune cells we set out to characterise and understand the bladder tumour microenvironment of 114 patients from a prospective multicentre cohort of newly-diagn...

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Veröffentlicht in:	PloS one 2017-09, Vol.12 (9), p.e0184841-e0184841
Hauptverfasser:	Dowell, Alexander C, Cobby, Ellen, Wen, Kaisheng, Devall, Adam J, During, Vinnie, Anderson, Jane, James, Nicholas D, Cheng, Kar K, Zeegers, Maurice P, Bryan, Richard T, Taylor, Graham S
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus Bacillus Calmette-Guerin vaccine BCG BCG Vaccine - therapeutic use Biology and Life Sciences Bladder Bladder cancer Cancer Cancer therapies Carcinoma in Situ - drug therapy Carcinoma in Situ - immunology Carcinoma in Situ - metabolism Care and treatment Cell adhesion & migration Cell Movement - drug effects Cell Proliferation - drug effects Cell survival Cytokines Development and progression Disease Progression Gene expression Genetic aspects Health risk assessment Health risks Hospitals Humans Immune response Immune system Immunology Immunotherapy Interleukin 17 Interleukin-17 - pharmacology Lymphocytes T Mast cells Mast Cells - drug effects Mast Cells - immunology Mast Cells - metabolism Medical prognosis Medical research Medicine and Health Sciences Patient outcomes Patients Physiological aspects Prospective Studies Public health Research and Analysis Methods Rheumatoid arthritis Risk factors Tumor Cells, Cultured Tumor microenvironment Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Tumors Urinary bladder Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - metabolism Urology Urothelial cancer
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Zusammenfassung:	The tumour immune microenvironment is considered to influence cancer behaviour and outcome. Using a panel of markers for innate and adaptive immune cells we set out to characterise and understand the bladder tumour microenvironment of 114 patients from a prospective multicentre cohort of newly-diagnosed bladder cancer patients, followed-up for 4.33±1.71 years. We found IL-17-positive cells were significantly increased in primary and concomitant carcinoma in situ (CIS), p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0184841