Nasopharyngeal bacterial load as a marker for rapid and easy diagnosis of invasive pneumococcal disease in children from Mozambique

Current diagnostic methods for detection of Streptococcus pneumoniae in children with suspected invasive pneumococcal disease have limitations of accuracy, timeliness, and patient convenience. This study aimed to determine the performance of pneumococcal load quantified with a real-time polymerase-c...

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Veröffentlicht in:PloS one 2017-09, Vol.12 (9), p.e0184762-e0184762
Hauptverfasser: Brotons, Pedro, Bassat, Quique, Lanaspa, Miguel, Henares, Desiree, Perez-Arguello, Amaresh, Madrid, Lola, Balcells, Reyes, Acacio, Sozinho, Andres-Franch, Maria, Marcos, Maria Angeles, Valero-Rello, Ana, Muñoz-Almagro, Carmen
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Sprache:eng
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Zusammenfassung:Current diagnostic methods for detection of Streptococcus pneumoniae in children with suspected invasive pneumococcal disease have limitations of accuracy, timeliness, and patient convenience. This study aimed to determine the performance of pneumococcal load quantified with a real-time polymerase-chain reaction in nasopharyngeal samples to diagnose invasive pneumococcal disease in children. Matched case-control study of patients
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0184762