Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity

Iron dysregulation is a potential contributor to the pathology of obesity-related metabolic complications. KK/HIJ (KK) mice, a polygenic obese mouse model, have elevated serum iron levels. A subset of KK male mice display a bronzing of epididymal adipose tissue (eAT) associated with >100-fold (p0...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0179889
Hauptverfasser:	Ma, Xiaoya, Pham, Vinh T, Mori, Hiroyuki, MacDougald, Ormond A, Shah, Yatrik M, Bodary, Peter F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Adiponectin - genetics Adipose tissue Adipose Tissue - metabolism Adipose Tissue - pathology Adiposity Alpha iron Analysis Animals Biology and Life Sciences Blood Glucose - metabolism Body fat Cell death Clustering Complications Cytokines Deposition Diabetes Diet Disease Models, Animal Endocrinology Epididymis - metabolism Epididymis - pathology Fasting Females Fibrosis Gene expression Genotype & phenotype Health aspects Histology Homeostasis Hypoxia Insulin Insulin Resistance Internal medicine Iron Iron - metabolism Iron content Iron Overload - genetics Iron Overload - metabolism Iron Overload - pathology Kinesiology Leptin Leptin - genetics Macrophages Male Males Medicine and Health Sciences Metabolism Mice Mice, Mutant Strains Nickel Nutrition research Obesity Obesity - genetics Obesity - metabolism Obesity - pathology Oxidative stress Pathology Physiology Remodeling Research and Analysis Methods Risk factors Rodents Stress concentration Studies Tissue Distribution Tissues Tumor necrosis factor Type 2 diabetes
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Zusammenfassung:	Iron dysregulation is a potential contributor to the pathology of obesity-related metabolic complications. KK/HIJ (KK) mice, a polygenic obese mouse model, have elevated serum iron levels. A subset of KK male mice display a bronzing of epididymal adipose tissue (eAT) associated with >100-fold (p0.05). The eAT histology revealed iron retention, macrophage clustering, tissue fibrosis, cell death as well as accumulation of HIF-2α in the high iron eAT. qPCR showed significantly decreased Lep (leptin) and AdipoQ (adiponectin), whereas Tnfα (tumor necrosis factor α), and Slc40a1 (ferroportin) were up-regulated in HI (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0179889