Tumor response assessment by MRI following stereotactic body radiation therapy for hepatocellular carcinoma

To evaluate the MRI features of a tumor response, local control, and predictive factors of local control after stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC). Thirty-five consecutive patients with 48 HCCs who were treated by SBRT were included in this retrospective stu...

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Veröffentlicht in:PloS one 2017-04, Vol.12 (4), p.e0176118-e0176118
Hauptverfasser: Oldrini, Guillaume, Huertas, Andres, Renard-Oldrini, Sophie, Taste-George, Hélène, Vogin, Guillaume, Laurent, Valérie, Salleron, Julia, Henrot, Philippe
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Sprache:eng
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Zusammenfassung:To evaluate the MRI features of a tumor response, local control, and predictive factors of local control after stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC). Thirty-five consecutive patients with 48 HCCs who were treated by SBRT were included in this retrospective study. All patients provided written informed consent to be treated by SBRT, and prior to inclusion they authorized use of the treatment data for further studies. The assessment was made using MRI, with determination of local and hepatic responses according to Response Evaluation Criteria in Solid Tumors (RECIST) and modified RECIST (mRECIST) criteria during a two-year follow-up. The local response rate according to mRECIST was higher than with RECIST. A tumor diameter less than 20 mm at baseline was an independent predictive factor for RECIST and mRECIST responses, as was diffusion-weighted signal for RECIST. During follow-up, a tumor diameter of
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0176118