Toxicity effects of di-(2-ethylhexyl) phthalate to Eisenia fetida at enzyme, cellular and genetic levels

Di-(2-ethylhexyl) phthalate (DEHP) is a dominant phthalic acid ester (PAE) that has aroused public concern due to its resistance to degradation and its toxicity as an endocrine-disrupting compound. Effects of different concentrations of DEHP on Eisenia fetida in spiked natural soil have been studied...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173957
Hauptverfasser:	Ma, Tingting, Zhou, Wei, Chen, Li'ke, Wu, Longhua, Christie, Peter, Zhang, Haibo, Luo, Yongming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Apoptosis Biology and Life Sciences Calcium - metabolism Cultivation Deoxyribonucleic acid Diethylhexyl Phthalate - toxicity Dioctyl phthalate DNA DNA Damage Dose-Response Relationship, Drug Ecology and Environmental Sciences Ecotoxicology Eisenia (Earthworms) Eisenia fetida Endocrine disruptors Environmental impact Enzymatic activity Enzyme activity Gene expression Gene Expression Regulation - drug effects Genetic aspects Heat shock proteins HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Intracellular Space - drug effects Intracellular Space - metabolism Laboratories Malondialdehyde Malondialdehyde - metabolism Medicine and Health Sciences Membrane potential Membrane Potential, Mitochondrial - drug effects Metallothionein Mitochondria Oligochaeta - cytology Oligochaeta - drug effects Oligochaeta - enzymology Oligochaeta - genetics Oxidative stress Peroxidase Peroxidase - metabolism Phthalic acid Physical Sciences Physiological aspects Pollutants Pollution Proteins Public concern Retention time Science Soil - chemistry Soil Pollutants - toxicity Soil sciences Soils Studies Superoxide dismutase Superoxide Dismutase - metabolism Tails Time Factors Toxicity Toxicity testing Worms
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Zusammenfassung:	Di-(2-ethylhexyl) phthalate (DEHP) is a dominant phthalic acid ester (PAE) that has aroused public concern due to its resistance to degradation and its toxicity as an endocrine-disrupting compound. Effects of different concentrations of DEHP on Eisenia fetida in spiked natural soil have been studied in the body of the earthworm by means of soil cultivation tests 7, 14, 21 and 28 days after exposure. The results indicated that, in general, superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, metallothionein (MT) content, the expression of heat shock protein 70 (HSP 70) and all the tested geno-toxicity parameters are promoted as time elapses and with increasing concentration of DEHP. However, peroxidase (POD) activity, neutral red retention time (NRRT) and mitochondrial membrane potential difference values were found to decrease even at a low concentration of DEHP of 1 mg kg-1 soil (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0173957