A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?

Licia Selleri * E-mail: Licia.Selleri@ucsf.edu (LSE); gbarsh@hudsonalpha.org (GSB) Affiliation: Program in Craniofacial Biology; Institute of Human Genetics; Eli and Edythe Broad Center of Regeneration Medicine & Stem Cell Research; Department of Orofacial Sciences & Department of Anatomy; University of California San Francisco, San Francisco, California, United States of America Marisa S. Bartolomei Affiliation: Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America Wendy A. Bickmore Affiliation: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom Lin He Affiliation: Division of Cellular and Developmental Biology, University of California Berkeley, Berkeley, California, United States of America Lisa Stubbs Affiliation: Institute for Genomic Biology, Department of Cell and Developmental Biology, University of Illinois, Urbana, Illinois, United States of America Wolf Reik Affiliation: Department of Epigenetics, The Babraham Institute, Cambridge, United Kingdom Gregory S. Barsh * E-mail: Licia.Selleri@ucsf.edu (LSE); gbarsh@hudsonalpha.org (GSB) Affiliations HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America, Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of AmericaCitation: Selleri L, Bartolomei MS, Bickmore WA, He L, Stubbs L, Reik W, et al. [...]the authors reported that derepressed genes in Hotair mutant tail tip fibroblasts, including multiple members of the HoxD but not HoxC clusters, exhibited loss of H3K27me3 and gain of H3K4me3 [5].