The Rise of FXR1: Escaping Cellular Senescence in Head and Neck Squamous Cell Carcinoma

[...]the viral oncoproteins E6 and E7 from human papillomavirus (HPV), which inhibit the tumor suppressors p53 and Rb, respectively, inactivate cellular senescence in response to oncogenic stress [6,7]. [...]infection with HPV, an important risk factor for subsets of head and neck squamous cell carcinoma (HNSCC), could promote tumorigenesis by inhibiting cellular senescence. Bypass of Cellular Senescence by FXR1 and Transformation FXR1 is a member of the Fragile X-related family of RNA-binding proteins, which also includes Fragile X Mental Retardation 1 (FMR1) and FXR2 and is frequently amplified in lung squamous cell carcinoma [9].