The miR165/166 Mediated Regulatory Module Plays Critical Roles in ABA Homeostasis and Response in Arabidopsis thaliana
The function of miR165/166 in plant growth and development has been extensively studied, however, its roles in abiotic stress responses remain largely unknown. Here, we report that reduction in the expression of miR165/166 conferred a drought and cold resistance phenotype and hypersensitivity to ABA...
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| Veröffentlicht in: | PLoS genetics 2016-11, Vol.12 (11), p.e1006416-e1006416 |
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| creator | Yan, Jun Zhao, Chunzhao Zhou, Jianping Yang, Yu Wang, Pengcheng Zhu, Xiaohong Tang, Guiliang Bressan, Ray A Zhu, Jian-Kang |
| description | The function of miR165/166 in plant growth and development has been extensively studied, however, its roles in abiotic stress responses remain largely unknown. Here, we report that reduction in the expression of miR165/166 conferred a drought and cold resistance phenotype and hypersensitivity to ABA during seed germination and post-germination seedling development. We further show that the ABA hypersensitive phenotype is associated with a changed transcript abundance of ABA-responsive genes and a higher expression level of ABI4, which can be directly regulated by a miR165/166 target. Additionally, we found that reduction in miR165/166 expression leads to elevated ABA levels, which occurs at least partially through the increased expression of BG1, a gene that is directly regulated by a miR165/166 target. Taken together, our results uncover a novel role for miR165/166 in the regulation of ABA and abiotic stress responses and control of ABA homeostasis. |
| doi_str_mv | 10.1371/journal.pgen.1006416 |
| format | Article |
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Here, we report that reduction in the expression of miR165/166 conferred a drought and cold resistance phenotype and hypersensitivity to ABA during seed germination and post-germination seedling development. We further show that the ABA hypersensitive phenotype is associated with a changed transcript abundance of ABA-responsive genes and a higher expression level of ABI4, which can be directly regulated by a miR165/166 target. Additionally, we found that reduction in miR165/166 expression leads to elevated ABA levels, which occurs at least partially through the increased expression of BG1, a gene that is directly regulated by a miR165/166 target. Taken together, our results uncover a novel role for miR165/166 in the regulation of ABA and abiotic stress responses and control of ABA homeostasis.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.1006416</identifier><identifier>PMID: 27812104</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abiotic stress ; Abscisic acid ; Abscisic Acid - genetics ; Arabidopsis - genetics ; Arabidopsis - growth & development ; Arabidopsis thaliana ; Authorship ; Biology ; Biology and Life Sciences ; Biosynthesis ; Droughts ; Ecology and Environmental Sciences ; Experiments ; Funding ; Gene Expression Regulation, Plant ; Genetic aspects ; Germination - genetics ; Homeostasis ; Homeostasis - genetics ; Horticulture ; Landscape architecture ; Medicine and Health Sciences ; Methods ; MicroRNA ; MicroRNAs - genetics ; Mutation ; Observations ; Physiological aspects ; Plant growth ; Plant sciences ; Plants, Genetically Modified - genetics ; Plants, Genetically Modified - growth & development ; RNA sequencing ; Roles ; Seedlings - genetics ; Seedlings - growth & development ; Seeds ; Seeds - genetics ; Seeds - growth & development ; Standard deviation ; Stress, Physiological - genetics</subject><ispartof>PLoS genetics, 2016-11, Vol.12 (11), p.e1006416-e1006416</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: . PLoS Genet 12(11): e1006416. doi:10.1371/journal.pgen.1006416</rights><rights>2016 Yan et al 2016 Yan et al</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: . 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Here, we report that reduction in the expression of miR165/166 conferred a drought and cold resistance phenotype and hypersensitivity to ABA during seed germination and post-germination seedling development. We further show that the ABA hypersensitive phenotype is associated with a changed transcript abundance of ABA-responsive genes and a higher expression level of ABI4, which can be directly regulated by a miR165/166 target. Additionally, we found that reduction in miR165/166 expression leads to elevated ABA levels, which occurs at least partially through the increased expression of BG1, a gene that is directly regulated by a miR165/166 target. Taken together, our results uncover a novel role for miR165/166 in the regulation of ABA and abiotic stress responses and control of ABA homeostasis.</description><subject>Abiotic stress</subject><subject>Abscisic acid</subject><subject>Abscisic Acid - genetics</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - growth & development</subject><subject>Arabidopsis thaliana</subject><subject>Authorship</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Biosynthesis</subject><subject>Droughts</subject><subject>Ecology and Environmental Sciences</subject><subject>Experiments</subject><subject>Funding</subject><subject>Gene Expression Regulation, Plant</subject><subject>Genetic aspects</subject><subject>Germination - genetics</subject><subject>Homeostasis</subject><subject>Homeostasis - genetics</subject><subject>Horticulture</subject><subject>Landscape architecture</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>MicroRNA</subject><subject>MicroRNAs - genetics</subject><subject>Mutation</subject><subject>Observations</subject><subject>Physiological aspects</subject><subject>Plant growth</subject><subject>Plant sciences</subject><subject>Plants, Genetically Modified - genetics</subject><subject>Plants, Genetically Modified - growth & development</subject><subject>RNA sequencing</subject><subject>Roles</subject><subject>Seedlings - genetics</subject><subject>Seedlings - growth & development</subject><subject>Seeds</subject><subject>Seeds - genetics</subject><subject>Seeds - growth & development</subject><subject>Standard deviation</subject><subject>Stress, Physiological - genetics</subject><issn>1553-7404</issn><issn>1553-7390</issn><issn>1553-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqVk11v0zAUhiMEYmPwDxBEQkJw0c6Ov5KbSWUCVmljqAxurZP4pPXkxiVOJvrvcdZuatEuhnxhy-d5X_sc-yTJa0rGlCl6fO37tgE3Xs2xGVNCJKfySXJIhWAjxQl_urM-SF6EcE0IE3mhnicHmcppRgk_TG6uFpgu7YxKcUylTC_QWOjQpDOc9w46367TC296h-l3B-uQnra2sxW4dOYdhtQ26eTTJD3zS_Shg2BDCs2gDivfBLyNt1Ba41dDrFuAs9DAy-RZDS7gq-18lPz88vnq9Gx0fvl1ejo5H1VKFN2olFnOmUEhGZCK1QKUyUVZ5lmhsrIgcTBjapRlnpeYxSIArwQWtZIZVtKwo-TtxnflfNDbkgVNc15IwRnPIzHdEMbDtV61dgntWnuw-nbDt3MNbczYoa4UL4xBqNFwLqUqaM2ASSaIUmgMjV4n29P6commwqZrwe2Z7kcau9Bzf6MFKbhSMhp82Bq0_nePodNLGyp0Dhr0_XBvEUEiJX8EyqRiguWD67t_0IcLsaXmEHO1Te3jFavBVE-4yjOV8XxIcfwAFYfBpa18g7WN-3uCj3uCyHT4p5tDH4Ke_pj9B_vt8ezlr332_Q67QHDdInjXdzb-0X2Qb8Cq9SG0WN-_HSV66Lq7yumh6_S266Lsze6734vu2oz9BcwXJOk</recordid><startdate>20161103</startdate><enddate>20161103</enddate><creator>Yan, Jun</creator><creator>Zhao, Chunzhao</creator><creator>Zhou, Jianping</creator><creator>Yang, Yu</creator><creator>Wang, Pengcheng</creator><creator>Zhu, Xiaohong</creator><creator>Tang, Guiliang</creator><creator>Bressan, Ray A</creator><creator>Zhu, Jian-Kang</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0284-2095</orcidid><orcidid>https://orcid.org/0000-0001-6043-4132</orcidid><orcidid>https://orcid.org/0000-0001-5134-731X</orcidid><orcidid>https://orcid.org/0000-0002-9133-0034</orcidid><orcidid>https://orcid.org/0000-0001-8181-4943</orcidid></search><sort><creationdate>20161103</creationdate><title>The miR165/166 Mediated Regulatory Module Plays Critical Roles in ABA Homeostasis and Response in Arabidopsis thaliana</title><author>Yan, Jun ; Zhao, Chunzhao ; Zhou, Jianping ; Yang, Yu ; Wang, Pengcheng ; Zhu, Xiaohong ; Tang, Guiliang ; Bressan, Ray A ; Zhu, Jian-Kang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c759t-b62843de563a0c3f5a7d85bb82972b909093ddfe6b88be2006a4c5e9f762ec6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abiotic stress</topic><topic>Abscisic acid</topic><topic>Abscisic Acid - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Jun</au><au>Zhao, Chunzhao</au><au>Zhou, Jianping</au><au>Yang, Yu</au><au>Wang, Pengcheng</au><au>Zhu, Xiaohong</au><au>Tang, Guiliang</au><au>Bressan, Ray A</au><au>Zhu, Jian-Kang</au><au>Yu, Hao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The miR165/166 Mediated Regulatory Module Plays Critical Roles in ABA Homeostasis and Response in Arabidopsis thaliana</atitle><jtitle>PLoS genetics</jtitle><addtitle>PLoS Genet</addtitle><date>2016-11-03</date><risdate>2016</risdate><volume>12</volume><issue>11</issue><spage>e1006416</spage><epage>e1006416</epage><pages>e1006416-e1006416</pages><issn>1553-7404</issn><issn>1553-7390</issn><eissn>1553-7404</eissn><abstract>The function of miR165/166 in plant growth and development has been extensively studied, however, its roles in abiotic stress responses remain largely unknown. Here, we report that reduction in the expression of miR165/166 conferred a drought and cold resistance phenotype and hypersensitivity to ABA during seed germination and post-germination seedling development. We further show that the ABA hypersensitive phenotype is associated with a changed transcript abundance of ABA-responsive genes and a higher expression level of ABI4, which can be directly regulated by a miR165/166 target. Additionally, we found that reduction in miR165/166 expression leads to elevated ABA levels, which occurs at least partially through the increased expression of BG1, a gene that is directly regulated by a miR165/166 target. Taken together, our results uncover a novel role for miR165/166 in the regulation of ABA and abiotic stress responses and control of ABA homeostasis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27812104</pmid><doi>10.1371/journal.pgen.1006416</doi><orcidid>https://orcid.org/0000-0003-0284-2095</orcidid><orcidid>https://orcid.org/0000-0001-6043-4132</orcidid><orcidid>https://orcid.org/0000-0001-5134-731X</orcidid><orcidid>https://orcid.org/0000-0002-9133-0034</orcidid><orcidid>https://orcid.org/0000-0001-8181-4943</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abiotic stress Abscisic acid Abscisic Acid - genetics Arabidopsis - genetics Arabidopsis - growth & development Arabidopsis thaliana Authorship Biology Biology and Life Sciences Biosynthesis Droughts Ecology and Environmental Sciences Experiments Funding Gene Expression Regulation, Plant Genetic aspects Germination - genetics Homeostasis Homeostasis - genetics Horticulture Landscape architecture Medicine and Health Sciences Methods MicroRNA MicroRNAs - genetics Mutation Observations Physiological aspects Plant growth Plant sciences Plants, Genetically Modified - genetics Plants, Genetically Modified - growth & development RNA sequencing Roles Seedlings - genetics Seedlings - growth & development Seeds Seeds - genetics Seeds - growth & development Standard deviation Stress, Physiological - genetics |
| title | The miR165/166 Mediated Regulatory Module Plays Critical Roles in ABA Homeostasis and Response in Arabidopsis thaliana |
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