Degenerative Suspensory Ligament Desmitis (DSLD) in Peruvian Paso Horses Is Characterized by Altered Expression of TGFβ Signaling Components in Adipose-Derived Stromal Fibroblasts

Equine degenerative suspensory ligament desmitis (DSLD) in Peruvian Paso horses typically presents at 7-15 years and is characterized by lameness, focal disorganization of collagen fibrils, and chondroid deposition in the body of the ligament. With the aim of developing a test for disease risk (that...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0167069-e0167069
Hauptverfasser:	Luo, Wei, Sandy, John, Trella, Katie, Gorski, Daniel, Gao, Shuguang, Li, Jun, Brounts, Sabrina, Galante, Jorge, Plaas, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 3 Adipose Tissue - pathology Animal husbandry Animals Biochemistry Biology and life sciences Bone surgery Breeding Chondroitin sulfate Chromatin - metabolism Collagen Fibrils Fibroblasts Fibroblasts - drug effects Fibroblasts - pathology Gene expression Gene Expression Regulation - drug effects Genes Growth factors Health risks Horse Diseases - pathology Horses Internal medicine Ligaments Male Medicine Medicine and Health Sciences Orthopedics Protein-Serine-Threonine Kinases - antagonists & inhibitors Pyrazoles - pharmacology Pyrroles - pharmacology Receptors, Transforming Growth Factor beta - antagonists & inhibitors Regulators Signal Transduction - drug effects Signaling Stem cells Stromal Cells - pathology Tendons Transforming Growth Factor beta - metabolism Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1
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Zusammenfassung:	Equine degenerative suspensory ligament desmitis (DSLD) in Peruvian Paso horses typically presents at 7-15 years and is characterized by lameness, focal disorganization of collagen fibrils, and chondroid deposition in the body of the ligament. With the aim of developing a test for disease risk (that can be used to screen horses before breeding) we have quantified the expression of 76 TGFβ-signaling target genes in adipose-derived stromal fibroblasts (ADSCs) from six DSLD-affected and five unaffected Paso horses. Remarkably, 35 of the genes showed lower expression (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0167069