Survival Outcomes in a Pediatric Antiretroviral Treatment Cohort in Southern Malawi

Pediatric uptake and outcomes in antiretroviral treatment (ART) programmes have lagged behind adult programmes. We describe outcomes from a population-based pediatric ART cohort in rural southern Malawi. Data were analyzed on children who initiated ART from October/2003 -September/2011. Demographics...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0165772-e0165772
Hauptverfasser:	Brophy, Jason C, Hawkes, Michael T, Mwinjiwa, Edson, Mateyu, Gabriel, Sodhi, Sumeet K, Chan, Adrienne K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adolescent Age AIDS Analysis Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Benzoxazines - therapeutic use Biology and Life Sciences CD4 Lymphocyte Count Child Child health Child, Preschool Children Cohort Studies Data processing Demographics Demography Dideoxynucleotides - therapeutic use Female Highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - mortality HIV Wasting Syndrome - mortality Human immunodeficiency virus Humans Infant Infants Lamivudine - therapeutic use Lentivirus Malawi - epidemiology Male Medical diagnosis Medicine and Health Sciences Mortality Mycobacterium Patients Pediatrics People and Places Proportional Hazards Models Retrospective Studies Retroviridae Rural Population Stavudine - analogs & derivatives Stavudine - therapeutic use Survival Survival Analysis Tuberculosis Tuberculosis, Pulmonary - mortality Urban environments Weight reduction Zidovudine - therapeutic use
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Beschreibung
Zusammenfassung:	Pediatric uptake and outcomes in antiretroviral treatment (ART) programmes have lagged behind adult programmes. We describe outcomes from a population-based pediatric ART cohort in rural southern Malawi. Data were analyzed on children who initiated ART from October/2003 -September/2011. Demographics and diagnoses were described and survival analyses conducted to assess the impact of age, presenting features at enrolment, and drug selection. The cohort consisted of 2203 children
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0165772