Reactive Oxygen Species: From Harmful Molecules to Fine-Tuning Regulators of Stem Cell Niche Maintenance

[...]in animals, hematopoietic stem cells (HSC)--which mostly reside in a quiescent state in the bone marrow--require low levels of ROS to maintain stem cell self-renewal. To understand how ROS regulate these processes at the molecular level, the authors investigated the expression of different gene...

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Veröffentlicht in:	PLoS genetics 2016-09, Vol.12 (9), p.e1006251-e1006251
1. Verfasser:	Del Pozo, Juan Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Cell division Cell growth Cell interactions Genotype & phenotype Hematopoietic stem cells Mitochondria Observations Oxygen Physiological aspects Reactive oxygen species Stem cells
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Zusammenfassung:	[...]in animals, hematopoietic stem cells (HSC)--which mostly reside in a quiescent state in the bone marrow--require low levels of ROS to maintain stem cell self-renewal. To understand how ROS regulate these processes at the molecular level, the authors investigated the expression of different genes involved in maintaining QC status, stem cell activity, or cell division.
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1006251