Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results

Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results

Electrogram-based identification of the regions maintaining persistent Atrial Fibrillation (AF) is a subject of ongoing debate. Here, we explore the concept of local electrical dyssynchrony to identify AF drivers. Local electrical dyssynchrony was calculated using mean phase coherence. High-density...

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Veröffentlicht in:PloS one 2016-10, Vol.11 (10), p.e0164236-e0164236
Hauptverfasser: Kuklik, Pawel, Schäffer, Benjamin, Hoffmann, Boris A, Ganesan, Anand N, Schreiber, Doreen, Moser, Julia M, Akbulak, Ruken Ö, Sultan, Arian, Steven, Daniel, Maesen, Bart, Schotten, Ulrich, Meyer, Christian, Willems, Stephan
Format: Artikel
Sprache:eng
Schlagworte:
Ablation
Ablation (Surgery)
Action potential
Aged
Analysis
Atrial fibrillation
Atrial Fibrillation - physiopathology
Atrial Fibrillation - surgery
Biology and Life Sciences
Cardiac arrhythmia
Cardiology
Catheter Ablation - methods
Catheters
Combined Modality Therapy
Complexity
Conduction
Density
Dynamic stability
Electric properties
Electrodes
Epicardial Mapping - methods
Female
Fibrillation
Heart
Heart Atria - physiopathology
Heart Atria - surgery
Humans
Male
Mapping
Mathematical analysis
Mathematical models
Medical instruments
Medicine
Medicine and Health Sciences
Middle Aged
Models, Theoretical
Patients
Phase coherence
Pilot Projects
Radiofrequency ablation
Regularization
Research and Analysis Methods
Thoracic surgery
Treatment Outcome
Veins & arteries
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Zusammenfassung:Electrogram-based identification of the regions maintaining persistent Atrial Fibrillation (AF) is a subject of ongoing debate. Here, we explore the concept of local electrical dyssynchrony to identify AF drivers. Local electrical dyssynchrony was calculated using mean phase coherence. High-density epicardial mapping along with mathematical model were used to explore the link between local dyssynchrony and properties of wave conduction. High-density mapping showed a positive correlation between the dyssynchrony and number of fibrillatory waves (R2 = 0.68, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0164236