Top-Down Network Effective Connectivity in Abstinent Substance Dependent Individuals

We hypothesized that compared to healthy controls, long-term abstinent substance dependent individuals (SDI) will differ in their effective connectivity between large-scale brain networks and demonstrate increased directional information from executive control to interoception-, reward-, and habit-r...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164818-e0164818
Hauptverfasser:	Regner, Michael F, Saenz, Naomi, Maharajh, Keeran, Yamamoto, Dorothy J, Mohl, Brianne, Wylie, Korey, Tregellas, Jason, Tanabe, Jody
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcohol Basal ganglia Biology and Life Sciences Brain Brain mapping Brain Mapping - methods Causality Cocaine Cognitive ability Comorbidity Computer and Information Sciences Control methods Correlation analysis Disease Drug abuse Drug dependence Drug Users - psychology Educational attainment Efficiency Emotions Executive function Female Functional magnetic resonance imaging Ganglia Graph theory Health care Humans Impulsive behavior Independent component analysis Longitudinal Studies Magnetic Resonance Imaging - methods Male Marijuana Medicine Medicine and Health Sciences Networks Neural networks Neuropsychological Tests Permutations Physical Sciences Predictive control Psychiatry Public health Reinforcement Remission Research and Analysis Methods School dropouts Social Sciences Template matching Thresholds Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We hypothesized that compared to healthy controls, long-term abstinent substance dependent individuals (SDI) will differ in their effective connectivity between large-scale brain networks and demonstrate increased directional information from executive control to interoception-, reward-, and habit-related networks. In addition, using graph theory to compare network efficiencies we predicted decreased small-worldness in SDI compared to controls. 50 SDI and 50 controls of similar sex and age completed psychological surveys and resting state fMRI. fMRI results were analyzed using group independent component analysis; 14 networks-of-interest (NOI) were selected using template matching to a canonical set of resting state networks. The number, direction, and strength of connections between NOI were analyzed with Granger Causality. Within-group thresholds were p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0164818