Fracture Risk in Relation to Serum 25-Hydroxyvitamin D and Physical Activity: Results from the EPIC-Norfolk Cohort Study

Fracture Risk in Relation to Serum 25-Hydroxyvitamin D and Physical Activity: Results from the EPIC-Norfolk Cohort Study

Vitamin D deficiency and physical inactivity have been associated with bone loss and fractures, but their combined effect has scarcely been studied either in younger or older adults. Therefore, we aimed to assess the associations between physical activity, age and 25-hydroxyvitamin D (25(OH)D) statu...

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Veröffentlicht in:PloS one 2016-10, Vol.11 (10), p.e0164160-e0164160
Hauptverfasser: Julian, Cristina, Lentjes, Marleen A H, Huybrechts, Inge, Luben, Robert, Wareham, Nick, Moreno, Luis A, Khaw, Kay-Tee
Format: Artikel
Sprache:eng
Schlagworte:
25-Hydroxyvitamin D
Adult
Adults
Age
Age Factors
Aged
Aged, 80 and over
Alcohol use
Alcoholic beverages
Biology and Life Sciences
Body mass
Body mass index
Body size
Bone Density
Bone loss
Cohort analysis
Cohort Studies
Exercise
Female
Fractures
Fractures (Injuries)
Fractures, Bone - epidemiology
Fractures, Bone - pathology
Health risk assessment
Humans
Incidence
Male
Medicine and Health Sciences
Middle Aged
Middle aged adults
Older people
People and Places
Physical activity
Physical fitness
Physical sciences
Proportional Hazards Models
Public health
Research and Analysis Methods
Risk
Risk Factors
Self Report
Sex Factors
Smoking
Social Sciences
Statistical models
Studies
Supplements
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin deficiency
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Zusammenfassung:Vitamin D deficiency and physical inactivity have been associated with bone loss and fractures, but their combined effect has scarcely been studied either in younger or older adults. Therefore, we aimed to assess the associations between physical activity, age and 25-hydroxyvitamin D (25(OH)D) status separately and in combination with the incidence of fracture risk in the EPIC-Norfolk cohort study. Baseline (1993-1998) self-reported physical activity and serum 25(OH)D concentrations at follow-up (1998-2000) were collected in 14,624 men and women (aged 42-82 y between 1998 and 2000). Fracture incidence was ascertained up to March 2015. Cox proportional hazard model was used to determine HRs of fractures by plasma 25(OH)D (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0164160