Viral Manipulation of Host Inhibitory Receptor Signaling for Immune Evasion

Eugenia Z. Ong Affiliation: Experimental Therapeutics Centre, Agency for Science, Technology, and Research, Singapore Kuan Rong Chan Affiliation: Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore Eng Eong Ooi * E-mail: engeong.ooi@duke-nus.edu.sg Affiliations Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore-MIT Alliance in Research and Technology, Infectious Diseases Interdisciplinary Group, SingaporeCitation: Ong EZ, Chan KR, Ooi EE (2016) Viral Manipulation of Host Inhibitory Receptor Signaling for Immune Evasion. [...]viruses that cause chronic diseases in humans utilize inhibitory signaling to impose T cell exhaustion, which greatly hampers response to disease treatment.