Functional Translational Readthrough: A Systems Biology Perspective
Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon....
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| Veröffentlicht in: | PLoS Genetics 2016-08, Vol.12 (8), p.e1006196-e1006196 |
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| container_title | PLoS Genetics |
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| creator | Schueren, Fabian Thoms, Sven |
| description | Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries. |
| doi_str_mv | 10.1371/journal.pgen.1006196 |
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FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.1006196</identifier><identifier>PMID: 27490485</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biology ; Biology and Life Sciences ; Codon, Terminator ; Computer and Information Sciences ; Drosophila melanogaster - genetics ; Eukaryotes ; Funding ; Genes ; Genetic research ; Genomics ; Humans ; Identification ; Localization ; Mammals ; Messenger RNA ; Peroxisomes - genetics ; Physical Sciences ; Protein Biosynthesis - genetics ; Proteins ; Research and Analysis Methods ; Review ; Ribosomes - genetics ; RNA polymerase ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Systems Biology ; Translation (Genetics) ; Viruses</subject><ispartof>PLoS Genetics, 2016-08, Vol.12 (8), p.e1006196-e1006196</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Schueren F, Thoms S (2016) Functional Translational Readthrough: A Systems Biology Perspective. PLoS Genet 12(8): e1006196. doi:10.1371/journal.pgen.1006196</rights><rights>2016 Schueren, Thoms 2016 Schueren, Thoms</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Schueren F, Thoms S (2016) Functional Translational Readthrough: A Systems Biology Perspective. 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| subjects | Animals Biology Biology and Life Sciences Codon, Terminator Computer and Information Sciences Drosophila melanogaster - genetics Eukaryotes Funding Genes Genetic research Genomics Humans Identification Localization Mammals Messenger RNA Peroxisomes - genetics Physical Sciences Protein Biosynthesis - genetics Proteins Research and Analysis Methods Review Ribosomes - genetics RNA polymerase RNA, Messenger - biosynthesis RNA, Messenger - genetics Systems Biology Translation (Genetics) Viruses |
| title | Functional Translational Readthrough: A Systems Biology Perspective |
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