Functional Translational Readthrough: A Systems Biology Perspective

Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon....

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Veröffentlicht in:	PLoS Genetics 2016-08, Vol.12 (8), p.e1006196-e1006196
Hauptverfasser:	Schueren, Fabian, Thoms, Sven
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Biology and Life Sciences Codon, Terminator Computer and Information Sciences Drosophila melanogaster - genetics Eukaryotes Funding Genes Genetic research Genomics Humans Identification Localization Mammals Messenger RNA Peroxisomes - genetics Physical Sciences Protein Biosynthesis - genetics Proteins Research and Analysis Methods Review Ribosomes - genetics RNA polymerase RNA, Messenger - biosynthesis RNA, Messenger - genetics Systems Biology Translation (Genetics) Viruses
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Beschreibung
Zusammenfassung:	Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries.
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1006196