Effect of Obesity on Acute Ozone-Induced Changes in Airway Function, Reactivity, and Inflammation in Adult Females

We previously observed greater ozone-induced lung function decrements in obese than non-obese women. Animal models suggest that obesity enhances ozone-induced airway reactivity and inflammation. In a controlled exposure study, we compared the acute effect of randomized 0.4ppm ozone and air exposures...

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Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0160030-e0160030
Hauptverfasser:	Bennett, William D, Ivins, Sally, Alexis, Neil E, Wu, Jihong, Bromberg, Philip A, Brar, Sukhdev S, Travlos, Gregory, London, Stephanie J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Adolescent Adult Air exposure Airway Animal models Biology and Life Sciences Biomarkers - metabolism Blood Body mass Body mass index Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - diagnosis Bronchial Hyperreactivity - metabolism C-reactive protein Case-Control Studies Causes of Double-Blind Method Earth Sciences Ecology and Environmental Sciences Exposure Female Females Forced Expiratory Volume Humans Inflammation - etiology Inflammation - metabolism Inflammation - pathology Influence Interleukin 1 Interleukin 6 Interleukin 8 Interleukins Leptin Leukocytes (neutrophilic) Lungs Medicine and Health Sciences Methacholine Obesity Obesity - complications Obesity - physiopathology Ozone Ozone - adverse effects Physical Sciences Physiological aspects Reactivity Research and Analysis Methods Respiratory function Respiratory System - drug effects Respiratory tract Respiratory tract diseases Rodents Smoking Sputum Tumor necrosis factor-α Womens health Young Adult
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Zusammenfassung:	We previously observed greater ozone-induced lung function decrements in obese than non-obese women. Animal models suggest that obesity enhances ozone-induced airway reactivity and inflammation. In a controlled exposure study, we compared the acute effect of randomized 0.4ppm ozone and air exposures (2 h with intermittent light exercise) in obese (N = 20) (30
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0160030