Major Sensing Proteins in Pathogenic Fungi: The Hybrid Histidine Kinase Family
[...]in fungi, knowledge is very fragmented, but initial studies in Saccharomyces cerevisiae have demonstrated that HKs also constitute the initial sensing proteins of a four-step phosphorelay signaling pathway that governs a cascade of mitogen-activated protein (MAP) kinases. http://dx.doi.org/10.1...
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| creator | Hérivaux, Anaïs So, Yee-Seul Gastebois, Amandine Latgé, Jean-Paul Bouchara, Jean-Philippe Bahn, Yong-Sun Papon, Nicolas |
| description | [...]in fungi, knowledge is very fragmented, but initial studies in Saccharomyces cerevisiae have demonstrated that HKs also constitute the initial sensing proteins of a four-step phosphorelay signaling pathway that governs a cascade of mitogen-activated protein (MAP) kinases. http://dx.doi.org/10.1371/journal.ppat.1005683.g001 It is now accepted that HKs are involved in cell signaling systems referred to as His-to-Asp phosphorelays and several canonical schemes depicting transduction pathways involving HKs in bacteria, amoebae, plants, and fungi have emerged (Fig 1B). Notably, with the exception of group VI HKs harboring transmembrane regions, most HKs are not predicted to be localized on the cell surface. [...]it will be intriguing to study how an environmental signal is translated into intracellular input signal for intracellular HKs and even a possibility that HKs may collaborate with other sensor proteins. |
| doi_str_mv | 10.1371/journal.ppat.1005683 |
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Notably, with the exception of group VI HKs harboring transmembrane regions, most HKs are not predicted to be localized on the cell surface. 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Notably, with the exception of group VI HKs harboring transmembrane regions, most HKs are not predicted to be localized on the cell surface. 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| subjects | Antifungal agents Bacteria Biology and Life Sciences Classification E coli Fungal Proteins Fungi Genes Genetic aspects Genomes Genomics Histidine Histidine Kinase Kinases Life Sciences Medicine and Health Sciences Microbiology and Parasitology Mycology Pathogenic fungi Pearls Physical Sciences Prokaryotes Proteins Research and Analysis Methods Signal transduction Transmitters |
| title | Major Sensing Proteins in Pathogenic Fungi: The Hybrid Histidine Kinase Family |
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