Major Sensing Proteins in Pathogenic Fungi: The Hybrid Histidine Kinase Family

[...]in fungi, knowledge is very fragmented, but initial studies in Saccharomyces cerevisiae have demonstrated that HKs also constitute the initial sensing proteins of a four-step phosphorelay signaling pathway that governs a cascade of mitogen-activated protein (MAP) kinases. http://dx.doi.org/10.1...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PLoS pathogens 2016-07, Vol.12 (7), p.e1005683-e1005683
Hauptverfasser: Hérivaux, Anaïs, So, Yee-Seul, Gastebois, Amandine, Latgé, Jean-Paul, Bouchara, Jean-Philippe, Bahn, Yong-Sun, Papon, Nicolas
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:[...]in fungi, knowledge is very fragmented, but initial studies in Saccharomyces cerevisiae have demonstrated that HKs also constitute the initial sensing proteins of a four-step phosphorelay signaling pathway that governs a cascade of mitogen-activated protein (MAP) kinases. http://dx.doi.org/10.1371/journal.ppat.1005683.g001 It is now accepted that HKs are involved in cell signaling systems referred to as His-to-Asp phosphorelays and several canonical schemes depicting transduction pathways involving HKs in bacteria, amoebae, plants, and fungi have emerged (Fig 1B). Notably, with the exception of group VI HKs harboring transmembrane regions, most HKs are not predicted to be localized on the cell surface. [...]it will be intriguing to study how an environmental signal is translated into intracellular input signal for intracellular HKs and even a possibility that HKs may collaborate with other sensor proteins.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1005683