Possible Mechanisms Underlying Aging-Related Changes in Early Diastolic Filling and Long Axis Motion-Left Ventricular Length and Blood Pressure

Possible Mechanisms Underlying Aging-Related Changes in Early Diastolic Filling and Long Axis Motion-Left Ventricular Length and Blood Pressure

The transmitral E wave and the peak velocity of early diastolic mitral annular motion (e`) both decrease with age, but the mechanisms underlying these age-related changes are incompletely understood. This study investigated the possible contributions of blood pressure (BP) and left ventricular end-d...

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Veröffentlicht in:PloS one 2016-06, Vol.11 (6), p.e0158302-e0158302
Hauptverfasser: Peverill, Roger E, Chou, Bon, Donelan, Lesley, Mottram, Philip M, Gelman, John S
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age
Aging
Aging (Biology)
Aging - physiology
Axis movements
Biology and Life Sciences
Blood
Blood Pressure
Body mass
Body mass index
Body measurements
Body size
Correlation analysis
Diagnosis
Diastole
Echocardiography, Doppler, Pulsed
Female
Heart
Heart failure
Heart murmurs
Heart Ventricles - diagnostic imaging
Heart Ventricles - growth & development
Humans
Hypertension
Influence
Male
Medicine
Medicine and Health Sciences
Middle Aged
Physical Sciences
Physiological aspects
Risk factors
Rodents
Social Sciences
Velocity
Ventricle
Ventricular Function, Left
Wall thickness
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Beschreibung
Zusammenfassung:The transmitral E wave and the peak velocity of early diastolic mitral annular motion (e`) both decrease with age, but the mechanisms underlying these age-related changes are incompletely understood. This study investigated the possible contributions of blood pressure (BP) and left ventricular end-diastolic length (LVEDL) to age-related reductions in E and e`. The study group were 82 healthy adult subjects
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0158302