Quantifying the Epidemiological Impact of Vector Control on Dengue

Results will provide a benchmark for subsequent trials in which combinations of interventions are assessed.\n Ignoring human movement during study design considerations would require an artificial increase in the expected effectiveness to achieve adequate power because every individual in a treatmen...

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Veröffentlicht in:PLoS neglected tropical diseases 2016-05, Vol.10 (5), p.e0004588
Hauptverfasser: Reiner, Jr, Robert C, Achee, Nicole, Barrera, Roberto, Burkot, Thomas R, Chadee, Dave D, Devine, Gregor J, Endy, Timothy, Gubler, Duane, Hombach, Joachim, Kleinschmidt, Immo, Lenhart, Audrey, Lindsay, Steven W, Longini, Ira, Mondy, Mathias, Morrison, Amy C, Perkins, T Alex, Vazquez-Prokopec, Gonzalo, Reiter, Paul, Ritchie, Scott A, Smith, David L, Strickman, Daniel, Scott, Thomas W
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Sprache:eng
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Zusammenfassung:Results will provide a benchmark for subsequent trials in which combinations of interventions are assessed.\n Ignoring human movement during study design considerations would require an artificial increase in the expected effectiveness to achieve adequate power because every individual in a treatment cluster will be predicted to have the "maximum" effect. Insights from such trials will help guide the scaling up of effective dengue control strategies, whether vector control alone or in combination with vaccines, and will be applicable to other Ae. aegypti-borne viral infections of current public health concern, such as chikungunya and Zika viruses.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0004588